化疗对晚期胃癌患者细胞免疫及调节T细胞的影响(1)
| 第1页 |
参见附件。
【摘要】目的：探讨晚期胃癌患者化疗前后细胞免疫及调节T细胞(Tregs)的变化及其临床价值。方法 采用流式细胞术检测健康志愿者及晚期胃癌患者化疗前后外周血CD4+T、CD8+T细胞及调节T细胞的比例变化。结果 晚期胃癌患者化疗前外周血CD4+T细胞所占比例和CD4+T/CD8+T均较化疗后低，且二者均低于健康对照组(P<0.05)。晚期胃癌患者CD4+CD25+T细胞和Tregs细胞所占比例化疗后较化疗前有所降低，二者均明显高于健康对照组。结论 化疗能明显减轻晚期胃癌患者的肿瘤免疫耐受，改善免疫状况。
【关键词】免疫调节T细胞；胃癌；化疗；细胞免疫；
【Abstract】Objective To investigate the changes of cellular immune function and CD4+ CD25+ regulatory T cells (Tregs) in peripheral blood of patients with advanced gastric cancer before and after chemotherapy and their clinical implications. Methods The proportion of CD4+ CD25+ Tregs among CD4+ T lymphocytes and the proportion of CD4+ and CD8+ T cells of PBMC in peripheral blood of 32 patients with advanced gastric cancer was determined by flow cytometry before 1 day and 1 week after chemotherapy ......
您现在查看是摘要介绍页，详见PDF附件。