HIV耐药的研究现状(4)
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Research development of HIV drug resistance
ZOU Wen， LIU Ying， WANG Jian*， GAO Guo-jian， DONG Ji-peng， XIAN Qing-fei
(AIDS Research Center， China Academy of Chinese Medical Sciences， Beijing 100700， China)
[Abstract] Highly active antiretroviral combination therapy significantly reduced the mortality， but in the high-speed copying， high genetic variation and drug selection pressure under the effect of the increasingly serious problem of drug resistance greatly weakened the role of HAART inhibit viral replication and reduce antiviral treatment. This paper reports the latest trends in HIV drug-resistance in order to develop anti-HIV drugs in clinical programs， research and development of new guidance anti-HIV-1 strategy to bring guidance.
[Key words] HIV drug resistance； epidemic situation
doi：10.4268/cjcmm20131530
[责任编辑 陈玲], 百拇医药(邹雯 刘颖 王健 高国建 董继鹏 咸庆飞)
Research development of HIV drug resistance
ZOU Wen， LIU Ying， WANG Jian*， GAO Guo-jian， DONG Ji-peng， XIAN Qing-fei
(AIDS Research Center， China Academy of Chinese Medical Sciences， Beijing 100700， China)
[Abstract] Highly active antiretroviral combination therapy significantly reduced the mortality， but in the high-speed copying， high genetic variation and drug selection pressure under the effect of the increasingly serious problem of drug resistance greatly weakened the role of HAART inhibit viral replication and reduce antiviral treatment. This paper reports the latest trends in HIV drug-resistance in order to develop anti-HIV drugs in clinical programs， research and development of new guidance anti-HIV-1 strategy to bring guidance.
[Key words] HIV drug resistance； epidemic situation
doi：10.4268/cjcmm20131530
[责任编辑 陈玲], 百拇医药(邹雯 刘颖 王健 高国建 董继鹏 咸庆飞)