均匀设计法优选祛斑凝胶剂基质处方(2)
[2] 单敏洁，王晓华，周黎霞. 归白散面膜倒模术治疗黄褐斑60例[J]. 河北中医，2010，32(12)：1794.
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Optimization of formulas of Quban gel by uniform design
GUO Hong-ye， YAN Xiao-ping*， YI Bo-wen， ZHENG Rui， KUANG Ying
(Xiyuan Hospital， China Academy of Chinese Medical Sciences， Beijing 100091， China)
[Abstract] Objective： To optimize formulas of Quban gel. Method： The U6 (62×3) uniform design was adopted to optimize gel formulas， with rheological parameters， such as viscosity and yield value in room temperature， viscosity and yield value in average temperature of skin， thixlotropy. Result： The optimum proportion of matrix was made of 1.0 g carbomer 940， 5 mL glycerin and pH value 5-6.Conclusion： The regression model for gel matrix quality and gel rheological parameters was established to directly reflect the impacting effect of various factors， and provide certain preference basis for the screening of gel matrix formulas. Quban gel prepared by the method was evenly distributed， moderately viscous and highly thixotropic
[Key words] uniform design； Quban gel； rheology； matrix formula
doi：10.4268/cjcmm20132317, 百拇医药(郭红叶 闫小平 伊博文 郑蕊 匡颖)
[3] 张宁，徐艳明，祁永华，等. 外用凝胶剂研究进展[J]. 黑龙江医药，2010，1(23)：92.
[4] 陈映红，刘荣. 复方血竭凝胶基质成型工艺分析[J]. 临床合理用药，2011，4(5A)：33.
[5] 宫莉萍，赵怀清. 老鹳草凝胶剂制备工艺[J]. 中国实验方剂学杂志，2011，17(24)：19.
[6] 王志钢，王艳姣，李慧，等.丹葛明目即型凝胶的制备研究[J]. 中国中药杂志，2012，37(1)：46.
[7] 方开泰，马长兴. 正交与均匀试验设计[M]. 北京：科学出版社， 2001：115.
[8] 郑俊民. 经皮给药新剂型[M]. 北京：人民卫生出版社， 2006：413.
[9] 张兆旺. 中药制剂学[M].2版. 北京：中国中医药出版社， 2007：268.
Optimization of formulas of Quban gel by uniform design
GUO Hong-ye， YAN Xiao-ping*， YI Bo-wen， ZHENG Rui， KUANG Ying
(Xiyuan Hospital， China Academy of Chinese Medical Sciences， Beijing 100091， China)
[Abstract] Objective： To optimize formulas of Quban gel. Method： The U6 (62×3) uniform design was adopted to optimize gel formulas， with rheological parameters， such as viscosity and yield value in room temperature， viscosity and yield value in average temperature of skin， thixlotropy. Result： The optimum proportion of matrix was made of 1.0 g carbomer 940， 5 mL glycerin and pH value 5-6.Conclusion： The regression model for gel matrix quality and gel rheological parameters was established to directly reflect the impacting effect of various factors， and provide certain preference basis for the screening of gel matrix formulas. Quban gel prepared by the method was evenly distributed， moderately viscous and highly thixotropic
[Key words] uniform design； Quban gel； rheology； matrix formula
doi：10.4268/cjcmm20132317, 百拇医药(郭红叶 闫小平 伊博文 郑蕊 匡颖)