独蒜兰的化学成分研究(7)
[24] Adelfo Reyes-Ramírez， Martha Leyte-Lugo， Mario Figueroa， et al. Synthesis， biological evaluation， and docking studies of gigantol analogs as calmodulin inhibitors [J]. Eur J Med Chem， 2011， 46(7)： 2699.
Chemical constituents from Pleione bulbocodioides
WANG Chao， HAN Shao-wei， CUI Bao-song， WANG Xiao-juan， LI Shuai*
(State Key Laboratory of Bioactive Substance and Function of Natural Medicines， Institute of Materia Medica，Chinese Academy of Medical Sciences and Peking Union Medical College， Beijing 100050， China)
[Abstract] Fourteen compoumds were isolated from the ethyl acetate portion of the 95% ethanolic extract of Pleione bulbocodioides by a combination of various chromatographic techniques including silica gel， ODS， macroporous adsorbent resin， Sephadex LH-20， and preparative HPLC， of which ten compoumds were phenanthrenes and dihydrophenanthrenes， two compoumds were bibenzyls， one was lignan and a sterol. Their structures were identified on the basis of spectroscopic data as monbarbatain A(1)， 2， 7， 2′-trihydroxy-4， 4′， 7′-trimethoxy-1， 1′- biphenanthrene(2)， blestriarene A(3)， pleionesin B(4)， shanciol H(5)， {7-hydroxy-7′-(4′-hydroxy-3′-methoxyphenyl)- 4-methoxy-9， 10， 7′， 8′-tetrahydrophenanthro[2， 3-b]furan-8′-yl} methyl acetate(6)， 1-p-hydroxybenzyl-4-methoxy phenanthrene-2， 7-diol(7)， 1-p-hydroxybenzyl-4-met-hoxy-9， 10-dihydrophenanthrene-2， 7-diol(8)， hircinol(9)， coelonin(10)， gigantol(11)， batatasin Ⅲ(12)， syringaresinol(13) and ergosta-4， 6， 8(14)， 22-tetraen-3-one(14). Compounds 1-3， 9， 13 and 14 were isolated from this genus for the first time.
[Key words] Pseudobulbus Cremastrae seu Pleiones； Pleione bulbocodioides； phenanthrene and dihydrophenanthrene； bibenzyl
doi：10.4268/cjcmm20140316
[责任编辑 孔晶晶], http://www.100md.com(王超 韩少伟 崔保松 王晓娟 李帅)
Chemical constituents from Pleione bulbocodioides
WANG Chao， HAN Shao-wei， CUI Bao-song， WANG Xiao-juan， LI Shuai*
(State Key Laboratory of Bioactive Substance and Function of Natural Medicines， Institute of Materia Medica，Chinese Academy of Medical Sciences and Peking Union Medical College， Beijing 100050， China)
[Abstract] Fourteen compoumds were isolated from the ethyl acetate portion of the 95% ethanolic extract of Pleione bulbocodioides by a combination of various chromatographic techniques including silica gel， ODS， macroporous adsorbent resin， Sephadex LH-20， and preparative HPLC， of which ten compoumds were phenanthrenes and dihydrophenanthrenes， two compoumds were bibenzyls， one was lignan and a sterol. Their structures were identified on the basis of spectroscopic data as monbarbatain A(1)， 2， 7， 2′-trihydroxy-4， 4′， 7′-trimethoxy-1， 1′- biphenanthrene(2)， blestriarene A(3)， pleionesin B(4)， shanciol H(5)， {7-hydroxy-7′-(4′-hydroxy-3′-methoxyphenyl)- 4-methoxy-9， 10， 7′， 8′-tetrahydrophenanthro[2， 3-b]furan-8′-yl} methyl acetate(6)， 1-p-hydroxybenzyl-4-methoxy phenanthrene-2， 7-diol(7)， 1-p-hydroxybenzyl-4-met-hoxy-9， 10-dihydrophenanthrene-2， 7-diol(8)， hircinol(9)， coelonin(10)， gigantol(11)， batatasin Ⅲ(12)， syringaresinol(13) and ergosta-4， 6， 8(14)， 22-tetraen-3-one(14). Compounds 1-3， 9， 13 and 14 were isolated from this genus for the first time.
[Key words] Pseudobulbus Cremastrae seu Pleiones； Pleione bulbocodioides； phenanthrene and dihydrophenanthrene； bibenzyl
doi：10.4268/cjcmm20140316
[责任编辑 孔晶晶], http://www.100md.com(王超 韩少伟 崔保松 王晓娟 李帅)