青蒿素生物合成分子机制及调控研究进展(10)
[64]Liu Y， Ye H C， Wang H， et al Molecular cloning， Escherichiacoli expression and genomic organization of squalene synthasegene from Artemisia annua[J]Acta Bot Sin，2003，45：608
[65]Zhang L， Jing F Y， Li F P， et al Development of transgenic Artemisia annua (Chinese wormwood) plants with an enhanced content of artemisinin， an effective antimalarial drug， by hairpinRNAmediated genesilencing[J] Biotechnol Appl Biochem，2009，52：199
[66]Cai Y， Jia J W， Crock J， et al AcDNA clone for βcaryophyllene synthase from Artemisia annua[J] Phytochemistry， 2002，61：523
[67]Chen J L， Fang H M， Ji Y P， et alArtemisinin biosynthesisenhancement in transgenic Artemisia annua plants by downregulation of the betacaryophyllene synthase gene[J] Planta Med， 2011，77：1759
[68]Han J， Wang H， Lundgren A， et al Effects of overexpression of AaWRKY1 on artemisinin biosynthesis in transgenic Artemisia annua plants[J] Phytochemistry， 2014， 102：89
[69]Ma D， Pu G， Lei C， et alIsolation and characterization of AaWRKY1， an Artemisia annua transcription factor that regulates the amorpha4，11diene synthase gene， a key gene of artemisinin biosynthesis[J] Plant Cell Physiol， 2009，50：2146
[70]Lu X， Jiang W， Zhang L， et al AaERF1 positively regulates the resistance to Botrytis cinerea in Artemisia annua[J] PLoS ONE， 2013， 8：e57657
[71]Lorenzo O， Chico J M， SanchezSerrano J J， et al Jasmonateinsensitive1 encodes a MYC transcription factor essentialto discriminate between different jasmonateregulated defenseresponses in Arabidopsis[J] Plant Cell， 2004， 16：1938
[72]Lu X， Zhang L， Zhang F， et al AaORA， a trichomespecific AP2/ERF transcription factor of Artemisia annua， is a positive regulator in the artemisinin biosynthetic pathway and in disease resistance to Botrytis cinerea[J] New Phytol， 2013， 198(4)：1191
[73]Shen Q， Yan T， Fu X， et al Transcriptional regulation of artemisinin biosynthesis in Artemisia annua L[J]Sci Bull，2016， 61(1)：18
[74]Yu Z X， Li J X， Yang C Q， et al The jasmonateresponsive AP2/ERF transcription factors AaERF1 and AaERF2 positively regulate artemisinin biosynthesis in Artemisia annua L[J] Mol Plant， 2012， 5：353
[75]Tan H， Xiao L， Gao S， et alTrichome and Artemisinin Regulator 1 is required for trichome development and artemisinin biosynthesis in Artemisia annua[J] Mol Plant，2015， 8：1396
[76]Zhang F， Fu X， Lv Z， et alA basic leucine zipper transcription factor， AabZIP1， connects abscisic acid signaling with artemisinin biosynthesis in Artemisia annua L[J] Mol Plant， 2015， 8：163, http://www.100md.com(谭何新 肖玲 周正张磊 陈万生)
[65]Zhang L， Jing F Y， Li F P， et al Development of transgenic Artemisia annua (Chinese wormwood) plants with an enhanced content of artemisinin， an effective antimalarial drug， by hairpinRNAmediated genesilencing[J] Biotechnol Appl Biochem，2009，52：199
[66]Cai Y， Jia J W， Crock J， et al AcDNA clone for βcaryophyllene synthase from Artemisia annua[J] Phytochemistry， 2002，61：523
[67]Chen J L， Fang H M， Ji Y P， et alArtemisinin biosynthesisenhancement in transgenic Artemisia annua plants by downregulation of the betacaryophyllene synthase gene[J] Planta Med， 2011，77：1759
[68]Han J， Wang H， Lundgren A， et al Effects of overexpression of AaWRKY1 on artemisinin biosynthesis in transgenic Artemisia annua plants[J] Phytochemistry， 2014， 102：89
[69]Ma D， Pu G， Lei C， et alIsolation and characterization of AaWRKY1， an Artemisia annua transcription factor that regulates the amorpha4，11diene synthase gene， a key gene of artemisinin biosynthesis[J] Plant Cell Physiol， 2009，50：2146
[70]Lu X， Jiang W， Zhang L， et al AaERF1 positively regulates the resistance to Botrytis cinerea in Artemisia annua[J] PLoS ONE， 2013， 8：e57657
[71]Lorenzo O， Chico J M， SanchezSerrano J J， et al Jasmonateinsensitive1 encodes a MYC transcription factor essentialto discriminate between different jasmonateregulated defenseresponses in Arabidopsis[J] Plant Cell， 2004， 16：1938
[72]Lu X， Zhang L， Zhang F， et al AaORA， a trichomespecific AP2/ERF transcription factor of Artemisia annua， is a positive regulator in the artemisinin biosynthetic pathway and in disease resistance to Botrytis cinerea[J] New Phytol， 2013， 198(4)：1191
[73]Shen Q， Yan T， Fu X， et al Transcriptional regulation of artemisinin biosynthesis in Artemisia annua L[J]Sci Bull，2016， 61(1)：18
[74]Yu Z X， Li J X， Yang C Q， et al The jasmonateresponsive AP2/ERF transcription factors AaERF1 and AaERF2 positively regulate artemisinin biosynthesis in Artemisia annua L[J] Mol Plant， 2012， 5：353
[75]Tan H， Xiao L， Gao S， et alTrichome and Artemisinin Regulator 1 is required for trichome development and artemisinin biosynthesis in Artemisia annua[J] Mol Plant，2015， 8：1396
[76]Zhang F， Fu X， Lv Z， et alA basic leucine zipper transcription factor， AabZIP1， connects abscisic acid signaling with artemisinin biosynthesis in Artemisia annua L[J] Mol Plant， 2015， 8：163, http://www.100md.com(谭何新 肖玲 周正张磊 陈万生)