真实世界的参芎葡萄糖注射液治疗脑梗死联合用药复杂网络分析(1)
[摘要]為分析真实世界参芎葡萄糖注射液治疗脑梗死的联合用药方案，提取全国16家三甲医院信息系统(HIS)数据库中使用参芎葡萄糖注射液治疗脑梗死患者的基本信息、中西医诊断信息、医嘱信息、实验室检查信息，采用Apriori算法建立模型，Clementine 120进行关联分析，采用复杂网络分析联合用药并将结果可视化。全国16家医院635例患者纳入分析，其中优效人群为599例，占9433%。参芎葡萄糖注射液治疗脑梗死常与西药的血小板抑制剂、神经修复药、降血脂药、自由基清除药、维生素类药及中药活血化瘀剂联合应用。优效人群在联合应用阿司匹林、降血脂药、活血化瘀剂的基础上，更多地应用了神经修复药和自由基清除药，突出了脑保护策略。参芎葡萄糖注射液治疗脑梗死的联合用药符合最新的脑梗死诊疗指南，应用神经保护剂有利于提高临床疗效。
[关键词]参芎葡萄糖注射液； 脑梗死； 联合用药； 真实世界； 医院信息系统； 复杂网络
Complex network analysis on Shenxiong glucose injection in combined
, 百拇医药
use with Chinese and Western medicine for cerebral
infarction in real world study
LIU Huan1， XIE Yanming1*， ZHANG Yin1， JIA Pingping2， ZHUANG Yan3
(1 Institute of Basic Medical Sciences， Chinese Academy of Traditional Chinese Medicine， Beijing 100700， China；
2 College of Statistics， Renmin University of China， Beijing 100872， China；
, 百拇医药
3 Navy PLA General Hospital， Beijing 100048， China)
[Abstract]In order to analyze Shenxiong glucose injection in combined use with other medicines for cerebral infarction in real world， the basic information， Chinese and western medicine diagnosis information， doctors’ advice information， and laboratory checking information for the patients with Shenxiong glucose injection in treatment of cerebral infarction were extracted from the hospital information system (HIS) of sixteen 3A hospitals Apriori Algorithm was used to establish models， and Clementine 120 was used for correlation analysis Then complex network was established to analyze the combined drug use and visualize the results A total of 635 patients were included in the study， among which 599 patients (9433%) showed superior effect Shenxiong glucose injection was often used with platelet suppressant drug， neuroprotective agent， lipid regulating agents， free radical scavenger， vitamins and Chinese medicine blood activating and stasis eliminating agent in the treatment of cerebral infarction In the patients with superior effect， neuroprotective agent and free radical scavengers were also used based on the combined use with Aspirin， hypolipidemic drugs and blood activating and stasis removing agents， highlighting the rain protection strategies Shenxiong glucose injection in combined use with Chinese and western medicines for cerebral infarction complied with the latest clinical practice guideline on the treatment of cerebral infarction， and the application of neuroprotective agent was propitious to improve the therapeutic effect
[Key words]Shenxiong glucose injection； cerebral infarction； combining use of Chinese and Western medicine； real world； hospital information system(HIS)； complex network analysis, http://www.100md.com(刘峘谢雁鸣张寅贾萍萍 庄严)
[关键词]参芎葡萄糖注射液； 脑梗死； 联合用药； 真实世界； 医院信息系统； 复杂网络
Complex network analysis on Shenxiong glucose injection in combined
, 百拇医药
use with Chinese and Western medicine for cerebral
infarction in real world study
LIU Huan1， XIE Yanming1*， ZHANG Yin1， JIA Pingping2， ZHUANG Yan3
(1 Institute of Basic Medical Sciences， Chinese Academy of Traditional Chinese Medicine， Beijing 100700， China；
2 College of Statistics， Renmin University of China， Beijing 100872， China；
, 百拇医药
3 Navy PLA General Hospital， Beijing 100048， China)
[Abstract]In order to analyze Shenxiong glucose injection in combined use with other medicines for cerebral infarction in real world， the basic information， Chinese and western medicine diagnosis information， doctors’ advice information， and laboratory checking information for the patients with Shenxiong glucose injection in treatment of cerebral infarction were extracted from the hospital information system (HIS) of sixteen 3A hospitals Apriori Algorithm was used to establish models， and Clementine 120 was used for correlation analysis Then complex network was established to analyze the combined drug use and visualize the results A total of 635 patients were included in the study， among which 599 patients (9433%) showed superior effect Shenxiong glucose injection was often used with platelet suppressant drug， neuroprotective agent， lipid regulating agents， free radical scavenger， vitamins and Chinese medicine blood activating and stasis eliminating agent in the treatment of cerebral infarction In the patients with superior effect， neuroprotective agent and free radical scavengers were also used based on the combined use with Aspirin， hypolipidemic drugs and blood activating and stasis removing agents， highlighting the rain protection strategies Shenxiong glucose injection in combined use with Chinese and western medicines for cerebral infarction complied with the latest clinical practice guideline on the treatment of cerebral infarction， and the application of neuroprotective agent was propitious to improve the therapeutic effect
[Key words]Shenxiong glucose injection； cerebral infarction； combining use of Chinese and Western medicine； real world； hospital information system(HIS)； complex network analysis, http://www.100md.com(刘峘谢雁鸣张寅贾萍萍 庄严)