【摘要】继发性甲状旁腺功能亢进(secondary hyperparathyroidism,SHPT)由长期低血钙、高血磷及低1,25-羟维生素D3[1,25(OH)2D3]刺激甲状旁腺代偿性增生,甲状旁腺激素(PTH)分泌增多而引起骨和电解质代谢异常,是慢性肾疾病(chronic kidney disease,CKD)常见并发症。随着肾脏病进展SHPT临床表现越明显,继发性甲旁亢高PTH引起骨丢失、全身和心血管的并发症,大大增加CKD患者死亡率。

    【关键词】甲状旁腺功能亢进;发病机制;治疗进展

    Sequential parathyroid function hyperfunction member pathogenesis and treatment progress

    Liu Jieqiong

    【Abstract】The sequential parathyroid function hyperfunction (secondary hyperparathyroidism, SHPT) by the long-term low serum calcium, Gao Xuelin and low 1,25- hydroxy Vitamin D3 [1,25 (OH) 2D3] stimulates the parathyroid redemptive proliferation, the parathyroid hormone (PTH) secretes increases causes the bone and the electrolyte metabolic anomalies, is the chronic kidney disease (chronic kidney disease, CKD) the common complication. Progresses the SHPT clinical manifestation along with renopathy to be more obvious, nearby the sequential armor high high PTH causes the bone to lose, the whole body and cardiovascular’s complication, increases the CKD patient mortality rate greatly. ......