糖尿病肾病大鼠肾组织周期素D1与周期素依赖性激酶4的表达及意义
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【摘要】 目的 探讨周期素D1(CyclinD1)与周期素依赖性激酶4(CDK4)在糖尿病肾病发生、进展中的作用。方法 通过注射链尿佐菌素建立糖尿病肾病大鼠模型，采用免疫组织化学法检测CyclinD1、CDK4的表达。结果 糖尿病肾病大鼠肾组织表现为系膜细胞等中、重度增生，CyclinD1、CDK4表达水平明显上调，二者呈正相关。结论 CyclinD1、CDK4参与了糖尿病肾病中肾固有细胞的增殖，是糖尿病肾病发生和进展的关键机制。
【关键词】 糖尿病肾病；大鼠；CyclinD1；CDK4
文章编号：1003-1383(2008)03-0245-03中图分类号：R 322.6+1 文献标识码：A
Expression and Significance of CyclinD1,
CDK4 in Nephridial Tissue of Rats Diabetic Nephropathy
YOU Yanwu,LIN Xu,YANG Fafen,WANG Jie,GUO Pengwei
(Dept. Nephrology,Affiliated Hospital,Youjiang Medical College for
Nationalities,Baise 533000,Guangxi China)
【Abstract】 Objective To investigate the expression and significance of CyclinD1,CDK4 in the occurrence, development of diabetic nephropathy.
Methods The rats model of diabetic nephropathy were established by injected STZ. The expression of CyclinD1,CDK4 were detected by immunohistochemistry.
Results The nephridial tissue of rats diabetic nephropathy present mesangial cells was found moderate to severe hyperplasy ......
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