应用抗抑郁药配合常规治疗冠心病患者临床疗效的探讨(1)
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【摘要】 目的 探讨抗抑郁药的应用对冠心病患者临床疗效的影响。
方法 对筛选出的60例冠心病合并抑郁情绪的患者按随机原则分为两组，实验组和对照组各30例。实验组进行冠心病常规药物治疗的同时加用抗抑郁药，对照组只进行常规药物治疗，两组分别于治疗前、治疗8周后各进行一次心电图检查和抑郁自评量表(SDS)测定，两组于治疗4周后再行一次SDS的测定，将所有的检查、测定结果列表进行比较。结果 实验组心电图症状的改变、SDS的评分改变与对照组比较差异有统计学意义(P<0.05或0.01)。结论 抗抑郁药配合常规治疗冠心病的疗效显著，值得在临床冠心病治疗中推广应用。
【关键词】 冠心病；抑郁；心电图
文章编号：1003-1383(2011)05-0553-03 中图分类号：R 541.4 文献标识码：A
doi:10.3969/j.issn.1003-1383.2011.05.003
Study of clinical efficacy of the application of combining antidepressants and
conventional treatment of patients with coronary disease
LIU Zhongchun
(Electrocardiographic Room, No.1 People's Hospital, Yancheng, Jiangsu, 224006)
【Abstract】 Objective To investigate the efficacy of the application of antidepressants on patients with coronary disease.
Methods 60 patients with coronary disease concurrent with depression were selected. According to statistics,they were randomly divided into two groups:the experimental group and the control group,with 30 members in
each group. The experimental group was treated with conventional coronary disease therapy plus antidepressants,while the control group was treated only with conventional therapy.Each group had electrocardiographic examination and SDStests before treatment and after 8 weeks of the experiment they had examinations and tests again.SDS tests were also conducted after 4 weeks of the treatment.All the results were collected in the end for comparing.
Results There was statistical difference in ECG changes and SDS scores of the experimental group and the control group(P<0.05 or 0.01 ).
Conclusion Antidepressants can enhance the effects of conventional coronary disease treatment. Such therapy is worth popularizing in the clinical treatment of coronary heart disease.
【Key words】coronary disease;depression;ECG
冠状动脉粥样硬化性心脏病是冠状动脉粥样硬化使血管腔狭窄或阻塞，或(和)因冠状动脉功能性改变(痉挛)导致心肌缺血缺氧或坏死而引起心脏病，统称为冠状动脉性心脏病，简称冠心病，也称缺血性心脏病。冠心病是动脉粥样硬化导致器官病变的最常见类型，也是严重危害人类健康的常见病。本病多发生于40岁以后，男性多于女性，脑力劳动者较多。我国本病不如欧美多见，仅占心脏病死亡数的10%～20%，其中以北京、天津最高，但近年来伴随着快节奏的生活方式有增多的趋势。冠心病发病的病因尚未完全明了，深入的研究表明，冠心病是多因素的疾病，为多种因素作用于不同环节所致。常见的有年龄、性别、血脂、血压、糖尿病等。冠心病的分类包括心绞痛、心肌梗死、心律失常、原发性心脏骤停等。我们于近年采用SDS量表[1]对我院心血管科住院的冠心病患者普遍进行一次测定 ......
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