氨氯地平片与依那普利联用治疗36例老年高血压的疗效观察(1)
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【摘要】 目的 评价氨氯地平片与依那普利联用治疗老年高血压的临床效果及安全性。方法 选择2008～2010年在本院确诊为高血压并接受药物治疗的72例老年患者。口服氨氯地平片组为对照组，口服氨氯地平片+依那普利组为研究组，每组36例。服药4周后进行疗效比较。结果 研究组总有效率为94.44%；对照组总有效率为75.00%。两组比较差异有统计学意义(P<0.05)。研究组DBP和SBP平均下降幅度明显多于对照组(P<0.05)。结论 氨氯地平片与依那普利联用治疗老年高血压疗效明显优于单用氨氯地平片治疗，且安全性良好，值得在临床上推广应用。
【关键词】 氨氯地平片；依那普利；联合用药；老年高血压
文章编号：1003-1383(2011)05-0559-03 中图分类号：R 544.1 文献标识码：A
doi:10.3969/j.issn.1003-1383.2011.05.005
Observation of the efficacy of combining Amlodipine tablets and Enalapril
to treat 36 cases with senile hypertension
HUANG Yin
(Beihai People's Hospital，Beihai 536000，Guangxi)
【Abstract】 Objective To evaluate clinical efficacy and safety of combining the amlodipine and enalapril tablets to treat senile hypertension.
Methods 72 cases of elderly patients who were diagnosed with senile hypertension and got treatment of drugs in hour hospital from 2008 to 2010 were selected.Those who have took amlodipine tablets fell under the control group，while those who took amlodipine tablets enalapril group fell under the study group，each group with 36 patients. Their efficacies were compared after 4 weeks of treatment.
Results The total effective rate of the study group was 94.44%, while that of the control group was 75.00%. Difference between the two groups was statistically significant(P<0.05). The average declining level of DBP and SBP of the study group was obviously higher than that of the control group(P<0.05).
Conclusion It is better and safer to use Amlodipine tablets combining with enalapril tablets thanto use amlodipine alone in treatment of senile hypertension. The combining treatment is worth clinical application.
【Key words】amlodipine tablets；enalapril；combination therapy；senile hypertension
高血压病是临床的常见病和多发病，近20年来高血压病患病率在我国呈增加趋势[1]。笔者采用氨氯地平片与依那普利联合治疗老年高血压，收到良好疗效，现报道如下。
资料与方法
1.研究对象 所选对象均来自本院2009年1月～2010年12月我院门诊患者共72例，诊断均符合中国高血压防治指南定义的高血压标准[2]。即未服抗高血压药情况下收缩压(SBP)≥140 mmHg和(或)舒张压(DBP)≥90 mmHg；平均血压值：SBP(170.0±25.0)mmHg，DBP(130.0±36.7)mmHg。经签署知情同意书，按就诊顺序将72例患者随机分为研究组和对照组各36例，研究组中男23例，女13例；平均年龄(61.30±5.30)岁。对照组中男24例，女12例；平均年龄(62.20±4.70)岁。均排除心肌梗死、脑卒中、严重的肾病史、严重心功能不全等病史患者 ......
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