肿瘤型丙酮酸激酶在宫颈癌血浆中的测定及其临床意义(1)
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【摘要】 目的 探讨血浆肿瘤型丙酮酸激酶(TuM2-PK)含量变化与宫颈癌发生的关系及其对宫颈癌的诊断价值。
方法 采用酶联免疫吸附试验(ELISA)测定30例正常人、35例慢性宫颈炎患者和32例宫颈癌患者血浆TuM2-PK水平，并以≥15 u/ml为阳性判断标准，以病理学为诊断金标准进行诊断试验。结果 宫颈癌组血浆TuM2-PK含量及阳性率均高于正常对照组、慢性宫颈炎组(P<0.01)；正常对照组与慢性宫颈炎组的血浆TuM2-PK含量及阳性率差异均无统计学意义(P>0.05)。血浆TuM2-PK检测宫颈癌的敏感度为84.4%，特异性为94.0%。结论 TuM2-PK是检测宫颈癌较为敏感的肿瘤标志物，具有较高的临床应用价值。
【关键词】 肿瘤标志物；肿瘤型丙酮酸激酶；宫颈癌
文章编号：1003-1383(2011)06-0703-03 中图分类号：R 711.74 文献标识码：A
doi:10.3969/j.issn.1003-1383.2011.06.006
A study on TuM2 pyruvate kinase in plasma of patients with cervical
carcinoma and their clinical significance
HUANG Weitong，QIU Yun，HUANG Mingchun
(Maternal and ChildHealth Hospital of Nanning，Nanning，530011，China)
【Abstract】 Objective To explore the relationship between the change of TuM2-PK level in plasma and the occurrence of cervical carcinoma and to investigate its diagnostic value for cervical carcinoma.
Methods TuM2-PK levels of 30 normal people,of 35 patients with chronic cervitis,and of 32 cases with cervical carcinoma were tested by ELISA. The level ≥15 u/ml was taken as the criteria of positive judgment, with pathology as diagnosis standard to take the test.
Results Plasma TuM2-PK levels and positive rates of the cervical carcinoma group were higher than those of the normal group and the chronic cervicitis group(P<0.01).However, the comparison of Plasma TuM2-PK levels and positive rates between the cervical carcinoma group and the chronic cervicitis group did not show statistical difference(P>0.05).The sensitivity of Plasma TuM2-PK to test cervical carcinoma was 84.8% and the specificity was 94.0%.
Conclusion TuM2-PK is considered to be very sensitive tumor marker and has high clinical value.
【Key words】 tumor marker；tumor typeM2 pyruvate kinase；cervical carcinoma
宫颈癌是常见的妇科肿瘤，占女性生殖系统恶性肿瘤50%以上，发病率居全球妇女恶性肿瘤的第2位[1]。我国估计每年有近10万新发病例，约占全球新发病例总数的1/5，每年约有3万妇女死于宫颈癌。宫颈癌已成为继乳腺癌之后威胁妇女健康和生命的第二大杀手。随着筛查方法和技术不断改进，宫颈癌阳性发现率也逐渐提高。但是，年轻妇女宫颈癌的发病率仍处于上升的趋势，发病因素也很复杂，除了与病毒感染有关外，是否与人体组织相关的丙酮酸激酶(pyruvate kinase，PK)表达有关系，至今文献报道甚少。肿瘤型丙酮酸激酶(tumor M2 pyruvate kinase,TuM2-PK)最早发现于肝癌细胞系中，其水平升高可见于多种肿瘤如胃肠道肿瘤、肺癌、神经内分泌肿瘤、肾细胞癌、胰腺癌、前列腺癌和甲状腺癌中 ......
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