慢性阻塞性肺疾病患者检测FDP和AT-Ⅲ的意义(1)
 |
| 第1页 |
参见附件。
【摘要】 目的 探讨慢性阻塞性肺疾病(COPD)患者检测纤维蛋白原降解产物(FDP)和抗凝血酶-Ⅲ(AT-Ⅲ)的意义。方法 选取COPD患者共120例，其中Ⅰ级组30例，Ⅱ级组30例，Ⅲ级组32例，Ⅳ级组28例，以同期进行健康体检的100例健康人群作为对照组，COPD患者及健康体检者均抽取外周静脉血3 ml，采用全自动血凝仪检测凝血酶原时间(PT)和凝血酶时间(TT)，采用ELISA法检测FDP，采用免疫浊度法测定AT-Ⅲ。结果 COPDⅠ～Ⅳ级患者的TT、PT与对照组比较差异均无统计学意义(P>0.05)。COPDⅠ～Ⅳ级患者FDP水平均显著高于对照组(P<0.01)，AT-Ⅲ水平均显著低于对照组(P<0.01)，并且各级COPD患者AT-Ⅲ水平比较差异均有统计学意义(P<0.01)。COPDⅠ～Ⅳ级患者FDP和AT-Ⅲ水平存在显著的负相关(r=-0.954，P<0.01)。结论 FDP和AT-Ⅲ检测对于COPD患者有无凝血功能障碍的监测实用性较强。
【关键词】 纤维蛋白原降解产物；抗凝血酶-Ⅲ；慢性阻塞性肺疾病
文章编号：1003-1383(2012)04-0484-03
中图分类号：R 563 文献标识码：A
doi:10.3969/j.issn.1003-1383.2012.04.012
Significance of detecting FDP and AT-Ⅲ in patients with chronic obstructive pulmonary disease
Abudusupuer?mijiti1,Tuerxunjiang?silamu2,TIAN Gang3
(1.Department of Respiratory,Tuberculosis Control Institution,Kashi 844000,Xinjiang;2.The Community Hospital Affiliated to Kashi First People’s Hospital,Kashi 844000,Xinjiang;3.Laboratory Department,Tianjin Public Security Hospital,Tianjin 300040)
[HJ1*6][HJ]
【Abstract】 Objective To explore the significance of detecting FDP and AT-Ⅲ in patients with chronic obstructive pulmonary disease(COPD).
Methods 120 patients with COPD were divided into GroupⅠ(30 cases),Group Ⅱ(30 cases),GroupⅢ(32 cases) and Group Ⅳ(28 cases).100 healthy check-up people were selected as the control group. 3 ml of peripheral venous blood was drawn from each of COPD patients and healthy check-up people. PT and TT of each group were detected by the hematopexis equipment and FDP was measured by ELISA,AT-Ⅲ by immunoblot assay.
Results Patients with COPD from GroupⅠto Group Ⅳ had much higher level of FDP,obviously lower level of AT-Ⅲ than the control group(P<0.05) while their TT and PT had no statistical difference(P>0.05).The difference of AT-Ⅲ of every group was significant(P<0 ......
您现在查看是摘要介绍页，详见PDF附件(3386kb)。