大环内酯类药物单用或联用对小儿支原体肺炎的疗效分析(1)
 |
| 第1页 |
参见附件。
【摘要】 目的 分析比较单用红霉素、单用阿奇霉素、二者联用对小儿支原体肺炎的临床疗效。方法 将住院的90例患儿随机分为三组。A组30例，予红霉素治疗，B组31例，予阿奇霉素治疗，C组29例，予红霉素+阿奇霉素治疗，三组药物的使用剂量、疗程相同。比较三组患儿治疗后体温、咳嗽、肺部啰音等临床症状改善时间以及肺部X线病灶消失时间。统计比较三组治疗的总有效率以及不良反应的发生情况。结果 三组患儿的退热时间、咳嗽消失时间、肺部啰音消失时间、X线病灶消失时间比较差异均有统计学意义(P<0.01),B组和C组的各观察指标时间显著短于于A组(P<0.01)。B组与C组之间差异无统计学意义(P>0.05)。三组总有效率比较差异有统计学意义(P<0.05)，C组显著高于A组(P<0.05)，B组与C组之间差异无统计学意义(P>0.05)。A组和C组患儿均可见胃肠、给药部位静脉炎、过敏、肝损害等不良反应。三组均以胃肠反应较为多见，其发生率差异有统计学意义(P<0.01),B组显著低于A、C组(P<0.01)。结论 单用阿奇霉素是一种有效且不良反应较少的治疗小儿支原体肺炎的方式。
【关键词】 红霉素；阿奇霉素；小儿；支原体肺炎；药物联用
文章编号：1003-1383(2012)04-0494-03
中图分类号：R 725.6 文献标识码：A
doi:10.3969/j.issn.1003-1383.2012.04.016
Efficacy of macrolide drugs alone or combinated on pediatric mycoplasma pneumonia
GU Feng
(Department of Pediatrics,the People’s Hospital of Ningguo,Ningguo 242300,Anhui)
【Abstract】 Objective To compare the clinical efficacy of erythromycin, azithromycin and their combination on pediatric mycoplasma pneumonia.
Methods 90 children with mycoplasma pneumonia in our hospital were divided into 3 groups:group A (30 cases treated with erythromycin),group B (31 cases treated with azithromycin) and group C (29 cases treated with erythromycin and azithromycin). All groups used the same dose of medicine and same period of time.After appropriate treatment, the time of alleviation of clinical symptoms such as fever,cough,pulmonary rates, and chest X-ray examinations were collected for comparing. The overall response rate and adverse reactions of these three groups were recorded and compared, too ......
您现在查看是摘要介绍页，详见PDF附件(3347kb)。