[摘 要]目的 分析液氮冷冻配合倍他米松注射治疗瘢痕疙瘩的临床疗效及安全性。方法 于2023年4月-10月，选取庆阳市中医医院收治的150例瘢痕疙瘩患者，随机分为对照组和观察组，每组75例。对照组采用倍他米松注射液治疗，观察组在对照组基础上配合液氮冷冻，比较两组临床疗效、复发情况、血清相关因子、疼痛及瘙痒症状、生活质量。结果 观察组治疗总有效率高于对照组，复发率低于对照组(P<0.05)；观察组治疗后TGF-β1水平低于对照组，bFGF、BMP-7水平高于对照组(P<0.05)；观察组治疗后疼痛、瘙痒症状评分低于对照组(P<0.05)；观察组生活质量各维度评分高于对照组(P<0.05)。结论 在瘢痕疙瘩疾病治疗中采用液氮冷冻配合倍他米松注射治疗的临床疗效良好，可通过调节血清相关因子，缓解疼痛、皮肤瘙痒症状，从而提高生活质量，且复发率较低。

    [关键词] 液氮冷冻；倍他米松注射液；瘢痕疙瘩

    [中图分类号] R751 [文献标识码] A [文章编号] 1004-4949(2024)12-0095-04

    Analysis of the Efficacy and Safety of Liquid Nitrogen Freezing Combined with Betamethasone Injection in the Treatment of Keloids

    LI Zhi-quan

    (Department of Dermatology and Venereology， Qingyang Hospital of Traditional Chinese Medicine， Qingyang 745000， Gansu， China)

    [Abstract]Objective To analyze the clinical efficacy and safety of liquid nitrogen freezing combined with betamethasone injection in the treatment of keloid. Methods From April to October 2023， 150 patients with keloid admitted to Qingyang Hospital of Traditional Chinese Medicine were selected and randomly divided into control group and observation group ......