[摘 要]目的 研究超皮秒激光联合微针导入氨甲环酸治疗黄褐斑的临床效果。方法 选择2022年6月-2023年5月上海玫瑰医疗美容医院美容皮肤科收治的64例黄褐斑患者为研究对象，采用随机数字表法分为对照组与观察组，各32例。对照组予以超皮秒激光治疗，观察组予以超皮秒激光联合微针导入氨甲环酸治疗，比较两组黄褐斑面积和严重指数评分、临床疗效、负面情绪及不良反应发生情况。结果 观察组治疗后黄褐斑面积和严重指数评分低于对照组(P<0.05)；观察组治疗总有效率为96.88%，高于对照组的78.13%(P<0.05)；观察组治疗后焦虑评分、抑郁评分低于对照组(P<0.05)；观察组不良反应发生率低于对照组(P<0.05)。结论 超皮秒激光联合微针导入氨甲环酸治疗黄褐斑的临床疗效良好，可有效缓解患者临床症状，改善不良情绪，且不良反应发生几率较低，是一种安全、有效的治疗方案。

    [关键词] 超皮秒激光；微针疗法；黄褐斑

    [中图分类号] R758.4+2 [文献标识码] A [文章编号] 1004-4949(2024)17-0036-04

    Clinical Effect of Picosecond Laser Combined with Microneedle Introduction of Tranexamic Acid in the Treatment of Chloasma

    SHU Hong

    (Beauty Dermatology Departmentof Shanghai Rose Medical Beauty Hospital， Shanghai 200070， China)

    [Abstract]Objective To study the clinical effect of picosecond laser combined with microneedle introduction of tranexamic acid in the treatment of chloasma. Methods A total of 64 patients with chloasma admitted to the Department of Cosmetic Dermatology， Shanghai Rose Medical Beauty Hospital from June 2022 to May 2023 were selected as the research objects. They were divided into control group and observation group by random number table method ......