[摘 要] 聚左旋乳酸(PLLA)是一种具有良好生物相容性、可生物降解的高分子聚合物，具有促进胶原蛋白再生和皮肤修复的作用。但对聚左旋乳酸微球注射后引起的反应机理研究尚不足，且对PLLA的研究多为面部医美方向。本文阐述了聚左旋乳酸微球在再生医美领域的作用反应机制及代谢途径，同时综述了聚左旋乳酸在面部、颈部、胸部、臀部、腹部、四肢医美方面的临床应用进展，并对注射PLLA后的不良反应进行了总结，提出了PLLA在医美领域发展的新方向。

    [关键词] 聚左旋乳酸；PLLA微球；再生医美

    [中图分类号] R622 [文献标识码] A [文章编号] 1004-4949(2024)20-0191-04

    Reaction Mechanism of Poly-L-lactic Acid of Regenerative Medicine in Aesthetic Field and its Clinical Application Progress

    YANG Yan， WU Lihong， SHI Quan

    (Shanghai Dongli Great Health Research Institute Co.， Ltd.， Shanghai 200062， China)

    [Abstract] Poly-L-lactic acid (PLLA) is a biodegradable polymer with good biocompatibility， which can promote collagen regeneration and skin repair. However， the research on the reaction mechanism caused by the injection of poly-L-lactic acid microspheres is still insufficient， and the research on PLLA is mostly in the direction of facial medical beauty. In this paper， the reaction mechanism and metabolic pathway of PLLA microspheres in regenerative medicine in aesthetic field were described. At the same time， the clinical application of PLLA in facial ......