咖啡酸片治疗慢性难治性ITP的临床研究(1)
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[摘要]目的 探讨泼尼松、硫唑嘌呤联合咖啡酸片治疗慢性难治性特发性血小板减少性紫癜(ITP)的疗效。方法 20例诊断为慢性难治性ITP患者随机分为观察组和对照组，观察组采用泼尼松、硫唑嘌呤联合咖啡酸片治疗，对照组采用泼尼松联合硫唑嘌呤治疗，并评估两组患者的近期及远期疗效和副作用。结果 两组近期疗效比较，差异无统计学意义(P>0.05)。观察组的远期疗效优于对照组，两组间比较差异具有统计学意义(P<0.05)。不良反应的指标的比较，两组间差异无统计学意义(P>0.05)。结论 泼尼松、硫唑嘌呤联合咖啡酸片可作为慢性难治性ITP的有效治疗手段之一。
关键词：咖啡酸片 慢性 难治性 特发性血小板减少性紫癜
Cinlincal observation of the combined regime including compound caffeic acid tablet and prednisone and azathioprine in treatment of chronic refractory idiopathic thrombocytopenlc purpura
Liu Feng, Xiao Ding-hua，Mo Dong-hua, et al. Department of Hematology，Affiliated Hospital of Guilin Medical College ，Guilin，541001，China.
【Abstract】Objective：To study the effectiveness of the combined regime including caffeic acid tablet and prednisone and azathioprine in treatment of chronic refractory ITP.
Method：The 20 chronic refractory ITP patients were radomly divided into experimental group and control group.Experimental group was given the combined regime including caffeic acid tablet and prednisone and azathioprine and control group was given prednisone and azathioprineand azathioprine. short-term and long-term reaction and side-effect in the two groups was evaluated. .
Result：Experimental group effective amelioration than control groupand long-term reaction，with statistical difference between the two groups(P<0.05)but there is no significant difference in the short-term between the two groups(P>0.05). There is no significant difference in side-effect between experimental group and control group(P>0.05).
Conclusion：The combined regime including caffeic acid tablet and prednisone and azathioprine is effective in treatment of chronic refractory idiopathic thrombocytopenlc purpura.
【Key word】caffeic acid tablet；chronic refractory idiopathic thrombocytopenlc purpura.
中图分类号：R554.6 文献标识码：B 文章编号： 1004-7484(2011)06-0001-03
慢性难治性特发性血小板减少性紫癜(简称慢性难治性ITP)的治疗至今尚无理想手段。普通ITP常常对多种常规治疗(激素、丙种球蛋白、免疫抑制剂、脾切除)有效，而这些治疗对难治性ITP综合征一般无明显疗效。与普通ITP不同，慢性难治性ITP难治且易复发。本次研究探索泼尼松、硫唑嘌呤联合咖啡酸片治疗慢性难治性ITP的疗效。
1资料与方法
1.1 一般资料
选择我科2005年1月至2010年12月，明确诊断为慢性难治性ITP住院患者20例【1】。纳入标准：1)所有患者均接受常规剂量的糖皮质激素治疗半年以上无效或依赖，皆于本院或外院已行脾切除术，经影像学检查未见副脾残留。均有不同程度的活动性出血症状 ......
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