探讨幽门螺杆菌与胃癌的关系(2)
Hp研究中有一些手段和途径目前应用较少，很值得一提：①Hp的基因库已经建立[4]，其对Hp菌株的致病特异性、药物筛选、疫苗研制等可能发挥巨大作用；②适合于不同研究需要的各种螺杆菌属动物模型的建立[9]将会为研究提供有效手段；③对儿童Hp感染的研究可减少许多影响因素而得出更可靠的结论。
Hp与胃癌关系的研究将是今后Hp研究的焦点，我们面临的将是新一轮更高难度研究的挑战.。在今后的研究中，胃肠病学家将比以往更需要基础学科专家的共同参与。
参考文献
[1] The Eurogast study group.An international association between helicobacter pylori infection and gastric cancer.Lancet,1993,341(8857):1359～1362
[2] Mcfarlane GA,Munro A.Helicobacter pylori and gastric cancer.Br J Surg.1997,84(9):1190～1199
[3] 张安田.幽门螺杆菌与胃癌关系的研究现状.中华消化杂志，1995，15(3)：127～128
[4] Cheli R,Crespi M,Testino G.Gastric cancer and helicobacter pylori:biologic and epidemiological inconsistencies.J Clin Gastroenterol,1998,26(1):3～6
[5] Forman D, Webb P, Parsonnet J. Helicobacter pylori and gastric cancer. Lancet, 1994;343:243-244
[6] Lee A, Dixon MF, Danon DJ. Local acid production and Helicobacter pylori: a unifying hypothesis of gastroduodenal disease. Eur J Gastroenterol Hepatol, 1995;7:461～465
[7] Goldstone AR, Quirke P, Dixon MF. Helicobacter pylori infection and gastric cancer. J Pathol, 1996;179:129～137
[8] Tomb JF, Wite O, Kerlavage RA. The complete genome sequence of the gastric pathogen Helicobacter pylori. Nature, 1997;388:539～547
[9] Fox JG. Review article: Helicobacter species and in vivo models of gastrointestinal cancer. Aliment Pharmacol Ther, 1998;12(Suppl 1):37～60, 百拇医药(刘康兵)
Hp与胃癌关系的研究将是今后Hp研究的焦点，我们面临的将是新一轮更高难度研究的挑战.。在今后的研究中，胃肠病学家将比以往更需要基础学科专家的共同参与。
参考文献
[1] The Eurogast study group.An international association between helicobacter pylori infection and gastric cancer.Lancet,1993,341(8857):1359～1362
[2] Mcfarlane GA,Munro A.Helicobacter pylori and gastric cancer.Br J Surg.1997,84(9):1190～1199
[3] 张安田.幽门螺杆菌与胃癌关系的研究现状.中华消化杂志，1995，15(3)：127～128
[4] Cheli R,Crespi M,Testino G.Gastric cancer and helicobacter pylori:biologic and epidemiological inconsistencies.J Clin Gastroenterol,1998,26(1):3～6
[5] Forman D, Webb P, Parsonnet J. Helicobacter pylori and gastric cancer. Lancet, 1994;343:243-244
[6] Lee A, Dixon MF, Danon DJ. Local acid production and Helicobacter pylori: a unifying hypothesis of gastroduodenal disease. Eur J Gastroenterol Hepatol, 1995;7:461～465
[7] Goldstone AR, Quirke P, Dixon MF. Helicobacter pylori infection and gastric cancer. J Pathol, 1996;179:129～137
[8] Tomb JF, Wite O, Kerlavage RA. The complete genome sequence of the gastric pathogen Helicobacter pylori. Nature, 1997;388:539～547
[9] Fox JG. Review article: Helicobacter species and in vivo models of gastrointestinal cancer. Aliment Pharmacol Ther, 1998;12(Suppl 1):37～60, 百拇医药(刘康兵)