Reprimo基因多态性与肺癌的研究进展(2)
由上可见，Reprimo基因多态性表达与肺癌的关系探讨仍属空白，研究其关系对于肺癌发生的分子机制以及评估肺癌的发生、发展及预后具有重要意义。
参考文献
[1] Nici L.The role of pulmonary rehabilitation in the lung cancer patient [J].Semin Respir Crit Care Med，2009，30(6)：670-674.
[2] Liu G，Zhou W，Christiani DC.Molecular epidemiology of non-small cell lung cancer.Semin Respir Crit Care Med，2005，26(3)：265-272.
[3] Fasching PA，Gayther S，Pearce L，et al.Role of genetic polymorphisms and ovarian cancer susceptibility[J].Mol Oncol，2009，3(2)：171-181.
, 百拇医药
[4] Ohki R，Nemoto J，Murasawa H，et al.Reprimo，a New Candidate Mediator of the p53-mediated Cell Cycle Arrest at the G2 Phase[J].Biol Chem，2000，275(30)：22627-22630.
[5] Bernal C，Aguayo F，Villarroel C，Vargas M，Díaz I，Ossandon FJ，Santibáez E，Palma M，Aravena E，Barrientos C，Corvalan AH.Reprimo as a potential biomarker for early detection in gastric cancer.Clin Cancer Res，2008 Oct 1，14(19)：6264-9.
[6] Sato N，Fukushima N，Matsubayashi H，Iacobuzio-Donahue CA，Yeo CJ，Goggins M.Aberrant methylation of Reprimo correlates with genetic instability and predicts poor prognosis in pancreatic ductal adenocarcinoma.，2006 Jul 15，107(2)：251-7
, 百拇医药
[7] Hamilton JP，Sato F，Jin Z，Greenwald BD，Ito T，Mori Y，Paun BC，Kan T，Cheng Y，Wang S，Yang J，Abraham JM，Meltzer SJ.Reprimo methylation is a potential biomarker of Barrett''s-Associated esophageal neoplastic progression.Clin Cancer Res，2006 Nov 15，12(22)：6637-42.
[8] Takahashi T，Suzuki M，Shigematsu H，Shivapurkar N，Echebiri C，Nomura M，Stastny V，Augustus M，Wu CW，Wistuba II，Meltzer SJ，Gazdar AF.Aberrant methylation of Reprimo in human malignancies.Int J Cancer，2005 Jul 1，115(4)：503-10.
, http://www.100md.com
[9] Suzuki M，Shigematsu H，Takahashi T，Shivapurkar N，Sathyanarayana UG，Iizasa T，Fujisawa T，Gazdar AF.Aberrant methylation of Reprimo in lung cancer.Lung Cancer，2005 Mar，47(3)：309-14.
[10] 王海，等.5-AzadC联合TSA对人胃癌SGC-7901细胞生长及 Reprimo基因表达的影响.安徽科技大学学报，2012，47(1)：1-4
[11] 罗峻，等.S100A2、Reprimo在胃腺癌中的表达及其临床意义.中华实验外科杂志，2008，25(6)：754-755.
[12] 姜蕊，于世英.非小细胞肺癌中Reprimo以及14-3-3 Σ基因启动子异常甲基化检测.肿瘤防治研究，2009，36(2)：106-109.
, http://www.100md.com
[13] Ye Z，Parry JM.Identification of polymorphisms in the human Reprimo gene using public EST data.Teratog Carcinog Mutagen[J]，2002，22(6)：485-493.
[14] Beasley WD，Beynon J，Jenkins GJ，et al.Reprimo 824 G>C and p53R2 4696 C>G single nucleotide polymorphisms and colorectal cancer：a case-control disease association study[J].Int J Colorectal Dis，2008，23(4)：375-381., 百拇医药(陈贤华 胡宏波)
参考文献
[1] Nici L.The role of pulmonary rehabilitation in the lung cancer patient [J].Semin Respir Crit Care Med，2009，30(6)：670-674.
[2] Liu G，Zhou W，Christiani DC.Molecular epidemiology of non-small cell lung cancer.Semin Respir Crit Care Med，2005，26(3)：265-272.
[3] Fasching PA，Gayther S，Pearce L，et al.Role of genetic polymorphisms and ovarian cancer susceptibility[J].Mol Oncol，2009，3(2)：171-181.
, 百拇医药
[4] Ohki R，Nemoto J，Murasawa H，et al.Reprimo，a New Candidate Mediator of the p53-mediated Cell Cycle Arrest at the G2 Phase[J].Biol Chem，2000，275(30)：22627-22630.
[5] Bernal C，Aguayo F，Villarroel C，Vargas M，Díaz I，Ossandon FJ，Santibáez E，Palma M，Aravena E，Barrientos C，Corvalan AH.Reprimo as a potential biomarker for early detection in gastric cancer.Clin Cancer Res，2008 Oct 1，14(19)：6264-9.
[6] Sato N，Fukushima N，Matsubayashi H，Iacobuzio-Donahue CA，Yeo CJ，Goggins M.Aberrant methylation of Reprimo correlates with genetic instability and predicts poor prognosis in pancreatic ductal adenocarcinoma.，2006 Jul 15，107(2)：251-7
, 百拇医药
[7] Hamilton JP，Sato F，Jin Z，Greenwald BD，Ito T，Mori Y，Paun BC，Kan T，Cheng Y，Wang S，Yang J，Abraham JM，Meltzer SJ.Reprimo methylation is a potential biomarker of Barrett''s-Associated esophageal neoplastic progression.Clin Cancer Res，2006 Nov 15，12(22)：6637-42.
[8] Takahashi T，Suzuki M，Shigematsu H，Shivapurkar N，Echebiri C，Nomura M，Stastny V，Augustus M，Wu CW，Wistuba II，Meltzer SJ，Gazdar AF.Aberrant methylation of Reprimo in human malignancies.Int J Cancer，2005 Jul 1，115(4)：503-10.
, http://www.100md.com
[9] Suzuki M，Shigematsu H，Takahashi T，Shivapurkar N，Sathyanarayana UG，Iizasa T，Fujisawa T，Gazdar AF.Aberrant methylation of Reprimo in lung cancer.Lung Cancer，2005 Mar，47(3)：309-14.
[10] 王海，等.5-AzadC联合TSA对人胃癌SGC-7901细胞生长及 Reprimo基因表达的影响.安徽科技大学学报，2012，47(1)：1-4
[11] 罗峻，等.S100A2、Reprimo在胃腺癌中的表达及其临床意义.中华实验外科杂志，2008，25(6)：754-755.
[12] 姜蕊，于世英.非小细胞肺癌中Reprimo以及14-3-3 Σ基因启动子异常甲基化检测.肿瘤防治研究，2009，36(2)：106-109.
, http://www.100md.com
[13] Ye Z，Parry JM.Identification of polymorphisms in the human Reprimo gene using public EST data.Teratog Carcinog Mutagen[J]，2002，22(6)：485-493.
[14] Beasley WD，Beynon J，Jenkins GJ，et al.Reprimo 824 G>C and p53R2 4696 C>G single nucleotide polymorphisms and colorectal cancer：a case-control disease association study[J].Int J Colorectal Dis，2008，23(4)：375-381., 百拇医药(陈贤华 胡宏波)