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由MDS进展为急性白血病患者线粒体DNA D—loop区的突变(2)
http://www.100md.com 2013年12月1日 靳红 张进 李向方
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    参见附件。

     圖1. 第1号标本测序发现nt16223出现C→T碱基置换突变

    图2. 第4号标本测序发现nt150出现C→T碱基置换突变

    参考文献:

    [1] Miyazono F, Schneider PM, Metzger R, et al . Mutations in the mitochondrial DNA D-Loop region occur frequently in adenocarcinoma in Barrett's esophagus[J]. Oncogene, 2002, 21(23):3780-3783.

    [2] Tan DJ, Bai RK, Wong LJ. Comprehensive scanning of somatic mitochondrial DNA mutations in breast cancer[J]. Cancer Res, 2002, 62(4):972-976.

    [3] Nirajan BG,Bhat NK,Avadhani NG.Preferential attack of mitochondrial DNA by aflatoxin B1 during hepatocarcinogenesis[J]. Seience, 2002, 215(4528):73-75.

    [4] Habano W, Sugai T, Nakamura SI, et al. Microsatellite instability and mutation of mitochondrial and nuclear DNA in gastric carcinoma[J]. Gastroenterology, 2000, 18 (5):835-841.

    [5] Nomoto S,Yamashita K,Koshikawa K, et al. Mitochondrial D-loop mutations as clonal markers in multicentric hepatocellular carcinoma and plasma[J]. Clin Cancer Res. 2008, 8(2):481-487.

    [6] Rosson D, Keshgegian AA. Frequent mutations in the mitochondrial control region DNA in breast tissue[J]. Cancer Lett, 2010, 215(1):89-94.

    [7] Gomez-Zaera M, Abril J, Gonzalez L, et al. Identification of somatic and germline mitochondrial DNA sequence variants in prostate cancer patients[J]. Mutat Res, 2006, 595(1-2):42-51.

    [8] Gattermann N. From sideroblastic anemia to the role of mitochondrial DNA mutations in myelodysplastic syndromes[J]. Leuk Res, 2010, 24(2):141-151.

    

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