比较奥美拉唑与兰索拉唑治疗胃溃疡的临床疗效(1)
【摘 要】目的：探讨奥美拉唑与兰索拉唑治疗胃溃疡的临床疗效。方法：选择2015年1月-2017年12月胃溃疡患者100例根据治疗方法分组。对照组给予奥美拉唑治疗，观察组则给予兰索拉唑治疗。比较两组疾病治疗有效率；胃溃疡愈合时间、腹痛消失时间、腹胀消失时间；治疗前后患者生活质量水平。结果：观察组疾病治疗有效率高于对照组，P<0.05；观察组胃溃疡愈合时间、腹痛消失时间、腹胀消失时间短于对照组，P<0.05；治疗前两组生活质量水平相近，P>0.05；治疗后观察组生活质量水平优于对照组，P<0.05。结论：兰索拉唑治疗胃溃疡的应用效果确切，可有效改善血压，加速血压达标，且无严重不良反应，安全有效，值得推广应用。
【关键词】奥美拉唑；兰索拉唑；胃溃疡；临床疗效
Abstract：Objective： To investigate the clinical efficacy of omeprazole and lansoprazole in treating gastric ulcer. Methods： 100 patients with gastric ulcer in December January 2015 -2017 were selected according to the treatment group. The control group was given omeprazole treatment， the observation group was treated with lansoprazole treatment. The effective rate of disease treatment， the healing time of gastric ulcer， the time of abdominal pain disappear and the time of abdominal distension were compared between the two groups， and the quality of life of patients before and after treatment was also compared. Results： the effective rate of disease treatment in the observation group was higher than that of the control group， P < 0.05. The healing time of gastric ulcer， the disappearance time of abdominal pain and the disappearance time of abdominal distension were shorter than that of the control group， P < 0.05； the quality of life of the two groups before the treatment was similar， P > 0.05， and the quality of life of the observation group was better than that of the control group， P < 0.05. Conclusion： the effect of lansoprazole in the treatment of gastric ulcer is accurate. It can effectively improve blood pressure， accelerate blood pressure to reach the standard， and have no serious adverse reaction. It is safe and effective. It is worth popularizing.
, http://www.100md.com
keyword： Omeprazole； lansoprazole； gastric ulcer； clinical curative effect
【中圖分类号】R573.1 【文献标识码】B 【文章编号】1005-0019(2018)03-00-01
胃溃疡为常见多发消化系统疾病，其发生和幽门螺杆菌感染之间关系密切，因此治疗胃溃疡关键在于幽门螺杆菌的根除，以改善症状，降低复发率，加速溃疡愈合[1]。本研究分析了兰索拉唑治疗胃溃疡的应用效果，报告如下。
1 资料与方法
1.1 一般资料
选择2015年1月-2017年12月胃溃疡患者100例根据治疗方法分组。观察组男21例，女29例；年龄27-58岁，平均(38.21±4.13)岁。对照组男23例，女27例；年龄28-57岁，平均(38.66±4.12)岁。两组一般资料无统计学差异。
, 百拇医药
1.2 方法
两组均给予阿莫西林1g/次，2次/d。甲硝唑0.4g/次，餐后服用，2次/d。枸橼酸铋220mg/次，2次/d。治疗4周。在此基础上，对照组给予奥美拉唑治疗，剂量为20mg/次，2次/d。口服治疗，治疗4周。观察组则给予兰索拉唑治疗。剂量为20mg/次，2次/d。治疗4周。
1.3 观察指标 比较两组疾病治疗有效率；胃溃疡愈合时间、腹痛消失时间、腹胀消失时间；治疗前后患者生活质量水平(用胃肠疾病生活质量(GIQLI)量表评价，越低越好)。
显效：症状显著改善或消失，幽门螺杆菌根除，溃疡愈合；有效：症状改善，溃疡有所缩小；无效：达不到上述标准。疾病治疗有效率为显效、有效百分率之和[2]。
1.4 统计学方法 SPSS15.0统计，为计量资料并作t检验，%表示计数资料作检验，P<0.05显示差异显著。, http://www.100md.com(艾广凤)
【关键词】奥美拉唑；兰索拉唑；胃溃疡；临床疗效
Abstract：Objective： To investigate the clinical efficacy of omeprazole and lansoprazole in treating gastric ulcer. Methods： 100 patients with gastric ulcer in December January 2015 -2017 were selected according to the treatment group. The control group was given omeprazole treatment， the observation group was treated with lansoprazole treatment. The effective rate of disease treatment， the healing time of gastric ulcer， the time of abdominal pain disappear and the time of abdominal distension were compared between the two groups， and the quality of life of patients before and after treatment was also compared. Results： the effective rate of disease treatment in the observation group was higher than that of the control group， P < 0.05. The healing time of gastric ulcer， the disappearance time of abdominal pain and the disappearance time of abdominal distension were shorter than that of the control group， P < 0.05； the quality of life of the two groups before the treatment was similar， P > 0.05， and the quality of life of the observation group was better than that of the control group， P < 0.05. Conclusion： the effect of lansoprazole in the treatment of gastric ulcer is accurate. It can effectively improve blood pressure， accelerate blood pressure to reach the standard， and have no serious adverse reaction. It is safe and effective. It is worth popularizing.
, http://www.100md.com
keyword： Omeprazole； lansoprazole； gastric ulcer； clinical curative effect
【中圖分类号】R573.1 【文献标识码】B 【文章编号】1005-0019(2018)03-00-01
胃溃疡为常见多发消化系统疾病，其发生和幽门螺杆菌感染之间关系密切，因此治疗胃溃疡关键在于幽门螺杆菌的根除，以改善症状，降低复发率，加速溃疡愈合[1]。本研究分析了兰索拉唑治疗胃溃疡的应用效果，报告如下。
1 资料与方法
1.1 一般资料
选择2015年1月-2017年12月胃溃疡患者100例根据治疗方法分组。观察组男21例，女29例；年龄27-58岁，平均(38.21±4.13)岁。对照组男23例，女27例；年龄28-57岁，平均(38.66±4.12)岁。两组一般资料无统计学差异。
, 百拇医药
1.2 方法
两组均给予阿莫西林1g/次，2次/d。甲硝唑0.4g/次，餐后服用，2次/d。枸橼酸铋220mg/次，2次/d。治疗4周。在此基础上，对照组给予奥美拉唑治疗，剂量为20mg/次，2次/d。口服治疗，治疗4周。观察组则给予兰索拉唑治疗。剂量为20mg/次，2次/d。治疗4周。
1.3 观察指标 比较两组疾病治疗有效率；胃溃疡愈合时间、腹痛消失时间、腹胀消失时间；治疗前后患者生活质量水平(用胃肠疾病生活质量(GIQLI)量表评价，越低越好)。
显效：症状显著改善或消失，幽门螺杆菌根除，溃疡愈合；有效：症状改善，溃疡有所缩小；无效：达不到上述标准。疾病治疗有效率为显效、有效百分率之和[2]。
1.4 统计学方法 SPSS15.0统计，为计量资料并作t检验，%表示计数资料作检验，P<0.05显示差异显著。, http://www.100md.com(艾广凤)
参见：首页 > 医疗版 > 疾病专题 > 消化内科 > 胃疾病 > 胃溃疡