左西孟旦对急性冠脉综合征合并急性心衰患者心功能及血清NT—pro BNP的影响(1)
【摘要】目的：探究急性冠脉综合征合并急性心衰患者采取左西孟旦治疗对心功能及血清N末端B型利钠肽原(NT-pro BNP)的影响。方法：选择2016年5月-2018年5月期间在商丘市第一人民医院治疗的60例急性冠脉综合征合并急性心衰患者作为研究对象，按随机数表法分为2组，各30例。对照组给予多巴酚丁胺治疗，观察组给予左西孟旦治疗，比较两组治疗前后心功能指标与血清NT-pro BNP水平。结果：观察组治疗后LVEF、CI、SV水平均较对照组高，差异有统计学意义(P<005)；观察组治疗后血清NT-pro-BNP水平低于对照组，差异有统计学意义(P<005)。结论：左西孟旦治疗急性冠状综合征合并急性心衰患者，具有良好疗效，可显著降低血清NT-pro-BNP水平，改善心功能指标，缓解病情。
【关键词】急性冠脉综合征；急性心衰；左西孟旦；心功能；血清NT-pro BNP
【中图分类号】R54331
, http://www.100md.com 【文献标志码】A
【文章编号】1005-0019(2018)07-001-01
Effect of levosimendan on cardiac function and serum NT-pro BNP in patients with acute coronary syndrome complicated with acute heart failure
Su Jiankang (Department of Cardiology， Department of Cardiology， Shangqiu First People's Hospital， Henan， Shangqiu， 476100)， CCU
Abstract Objective：To explore the effect of levosimendan therapy on cardiac function and B type natriuretic peptide (NT-pro BNP) in patients with acute coronary syndromes with acute heart failure (ACS).Methods： 60 patients with acute coronary syndromes and acute heart failure treated in Shangqiu First People's Hospital during May -2018 May 2016 were selected as the research subjects， and were divided into 2 groups according to the random number table method， each 30 cases. The control group was given dobutamine treatment， while the observation group was given levosimendan treatment. The cardiac function indexes and serum NT-pro BNP levels were compared between the two groups before and after treatment. Results： the level of LVEF， CI and SV in the observation group was higher than that of the control group (P < 005)， and the serum NT-pro-BNP level in the observation group was lower than that of the control group， the difference was statistically significant (P < 005). Conclusion： levosimendan has a good curative effect in the treatment of acute coronary syndrome with acute heart failure. It can significantly reduce the level of serum NT-pro-BNP， improve the index of cardiac function and alleviate the disease.
, 百拇医药
Key words： acute coronary syndrome； acute heart failure； levosimendan； cardiac function； serum NT-pro BNP
急性冠脈综合征属于急性冠心病之一，由于急性心肌缺血而导致心血管疾病，急性心力衰竭是其严重并发症之一，具有较高的死亡率。多巴酚丁胺为常用治疗药物，可增强心肌收缩力，降低外周血管阻力，促进心排血量增加，使心室充盈压力降低，促进房室结传导，改善心力衰竭或心肌梗死所致的术后低血压及心源性休克[1]。左西孟旦可提高心肌收缩蛋白对钙离子的敏感性，提高心肌收缩力，但不会增加细胞内钙离子浓度与心肌耗氧量，促进心功能改善[2]。本研究旨在探讨多巴酚丁胺与左西孟旦治疗急性冠脉综合征合并急性心衰对心功能与血清NT-pro-BNP的影响。现报道如下。
1资料与方法
11一般资料选择2016年5月-2018年5月期间在商丘市第一人民医院治疗的60例急性冠脉综合征合并急性心衰患者作为研究对象，按随机数表法分为2组，各30例。对照组男17例，女13例；年龄49-76岁，平均(6237±422)岁。观察组男16例，女14例；年龄50-77岁，平均(6241±426)岁。两组一般资料相比，差异无统计学意义(P>005)，具有可比性。本研究经我院伦理委员会批准，患者同意参与本研究并签署知情书。, 百拇医药(苏健康)
【关键词】急性冠脉综合征；急性心衰；左西孟旦；心功能；血清NT-pro BNP
【中图分类号】R54331
, http://www.100md.com 【文献标志码】A
【文章编号】1005-0019(2018)07-001-01
Effect of levosimendan on cardiac function and serum NT-pro BNP in patients with acute coronary syndrome complicated with acute heart failure
Su Jiankang (Department of Cardiology， Department of Cardiology， Shangqiu First People's Hospital， Henan， Shangqiu， 476100)， CCU
Abstract Objective：To explore the effect of levosimendan therapy on cardiac function and B type natriuretic peptide (NT-pro BNP) in patients with acute coronary syndromes with acute heart failure (ACS).Methods： 60 patients with acute coronary syndromes and acute heart failure treated in Shangqiu First People's Hospital during May -2018 May 2016 were selected as the research subjects， and were divided into 2 groups according to the random number table method， each 30 cases. The control group was given dobutamine treatment， while the observation group was given levosimendan treatment. The cardiac function indexes and serum NT-pro BNP levels were compared between the two groups before and after treatment. Results： the level of LVEF， CI and SV in the observation group was higher than that of the control group (P < 005)， and the serum NT-pro-BNP level in the observation group was lower than that of the control group， the difference was statistically significant (P < 005). Conclusion： levosimendan has a good curative effect in the treatment of acute coronary syndrome with acute heart failure. It can significantly reduce the level of serum NT-pro-BNP， improve the index of cardiac function and alleviate the disease.
, 百拇医药
Key words： acute coronary syndrome； acute heart failure； levosimendan； cardiac function； serum NT-pro BNP
急性冠脈综合征属于急性冠心病之一，由于急性心肌缺血而导致心血管疾病，急性心力衰竭是其严重并发症之一，具有较高的死亡率。多巴酚丁胺为常用治疗药物，可增强心肌收缩力，降低外周血管阻力，促进心排血量增加，使心室充盈压力降低，促进房室结传导，改善心力衰竭或心肌梗死所致的术后低血压及心源性休克[1]。左西孟旦可提高心肌收缩蛋白对钙离子的敏感性，提高心肌收缩力，但不会增加细胞内钙离子浓度与心肌耗氧量，促进心功能改善[2]。本研究旨在探讨多巴酚丁胺与左西孟旦治疗急性冠脉综合征合并急性心衰对心功能与血清NT-pro-BNP的影响。现报道如下。
1资料与方法
11一般资料选择2016年5月-2018年5月期间在商丘市第一人民医院治疗的60例急性冠脉综合征合并急性心衰患者作为研究对象，按随机数表法分为2组，各30例。对照组男17例，女13例；年龄49-76岁，平均(6237±422)岁。观察组男16例，女14例；年龄50-77岁，平均(6241±426)岁。两组一般资料相比，差异无统计学意义(P>005)，具有可比性。本研究经我院伦理委员会批准，患者同意参与本研究并签署知情书。, 百拇医药(苏健康)
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