血清尿酸水平与冠心病关系的探讨(1)
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【摘要】目的 探讨血清尿酸水平与冠心病的相关性。方法 选择经冠状动脉造影证实的冠心病患者180例,分为急性冠脉综合征(ACS)组及稳定型心绞痛(SAP)组,同期冠脉造影正常的住院患者50例作为对照组;分别测定血清尿酸(SUA)及血脂水平,并记录分析性别、年龄、吸烟、高血压、糖尿病等病史。结果 冠心病患者血清尿酸水平显著高于对照组(P<0.05),且3组中血尿酸水平在ACS组最高,其次为SAP组,最后为对照组(P<0.05)差异有统计学意义。结论 血清尿酸水平可以作为冠心病的一个重要预测因子，血清尿酸水平升高是冠心病的危险因素之一，早期进行血清尿酸水平干预有可能预防及减少心血管事件的发生。
【关键词】血清尿酸 冠心病 危险因素
中图分类号：R541.4文献标识码：A文章编号：1005-0515(2011)1-035-02
Study on the relationship between the level of serum uric acid and coronary heart disease
PENG HuiBingHUANG HeWU MingXingHUANG HaoBoXIE LiQiang
Department of Cardiovasology, The centralHospital of Xiangtan, 411100, China
【Abstract】Objective To investigate the association between serum uric acid(SUA)and coronary heart disease(CHD).Methods 180 patients with CHD confirmed by angiography and 50 control subjects without CHD were included in this study.The CHD group was re-divide into two subgroups:acute coronary syndrome(120),stable angina pectoris(60).Serum uric acid and blood lipid were determined.The relative factors of coronary heart disease:gender,age,smoking, hypertension and diabetes mellitus were registered and analysed.Results The serum uric acid level in CHD group was significantly higher than that of the non-CHD group(P<0.05).And three groups of uric acid in the ACS group was the highest, followed by the SAP group, and finally the control group.There was signaficant difference in the level among the three groups (P<0.05).Couclusion The Serum uric acid level can be used as an important predictor of coronary heart disease.Elevated serumuric acid is one risk factor for CHD.The serum uric acid level of early intervention may prevent and reduce the incidence of cardiovascular events.
【Key words】Serum uric acid Coronary heart disease Risk factor
近年来,大量研究表明,除高血压、高血脂、高血糖、胰岛素抵抗、吸烟等危险因素外,血清尿酸水平在冠心病患者中升高的现象已引起临床的重视,随血清尿酸(serum uric acid,SUA)水平的增加,致死性和非致死性心血管事件明显增加[1]。但尿酸与临床事件的关联是由尿酸与其他危险因素之间的相互作用引起的，尿酸升高是否为冠心病的“独立”危险因素一直存在争议。本研究观察了180例冠心病患者的血清尿酸水平,以探讨SUA水平与冠心病之间的关系。
1 资料与方法
1.1 研究对象 收集2006年6月—2009年1月在我院心内科住院拟诊冠心病的患者230例，均存在冠心病危险因素并完善冠状动脉造影检查。根据冠状动脉造影结果分为冠心病组180例和非冠心病组50例(对照组)。冠心病组又根据美国心脏病协会制定的不稳定心绞痛诊断标准及世界卫生组织(WHO)制定的急性心肌梗死诊断标准,分为ACS患者120例(急性心肌梗死78例,不稳定型心绞痛42例),年龄(62 ......
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