甘精胰岛素联合瑞格列奈治疗2型糖尿病疗效观察(1)
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【摘要】目的 观察甘精胰岛素联合瑞格列奈治疗2型糖尿病的疗效。方法 选择我院2009年1月-2010年1月新入院确诊的2型糖尿病患者共70例作为观察对象，随机分为观察组和对照组各35例，观察组予甘精胰岛素加瑞格列奈治疗，甘精胰岛素起始剂量10U，每日一次，瑞格列奈0.5～2mg三餐前口服。对照组予丹纳胰岛素泵持续注射诺和灵R，，分析并比较其治疗前后空腹血糖(FBG)、餐后2小时血糖(PBG)、糖化血红蛋白(HbA1c)变化。结果 经治疗后，两组FBG、2hBG、HbAlc与治疗前相比均明显降低，且观察组上述指标降低较对照组更明显，差异具有显著性(P<0.05)。 观察组的总有效率明显高于对照组，差异具有显著性(P<0.05)。结论 甘精胰岛素联合瑞格列奈治疗2型糖尿病能给有效控制血糖，显著改善胰岛β细胞功能及胰岛素敏感性。
【关键词】2型糖尿病 甘精胰岛素 瑞格列奈
中图分类号：R587.1 文献标识码：A 文章编号：1005-0515(2011)7-045-02
Insulin glargine combined effect of repaglinide in type 2 diabetes observed
【Abstract】Objective To observe the joint repaglinide insulin glargine treatment of type 2 diabetic patients. Methods A hospital in January 2009 -2010 a new hospital in January with type 2 diabetes diagnosed 70 cases as the object of observation were randomly divided into two groups and the control group 35 patients in the observation group to glargine Jiarui Ge Chennai column treatment, starting dose of insulin glargine 10U, once a day, repaglinide 0.5 ~ 2mg orally before meals. Control group received a continuous infusion of insulin pump Danner Novolin R, analyzed and compared before and after treatment fasting blood glucose (FBG), postprandial 2 h blood glucose (PBG), glycosylated hemoglobin (HbA1c) change. Results After treatment, two groups of FBG, 2hBG, HbAlc compared with that before treatment were significantly decreased, and the observation group, these indexes decreased more significantly than the control group, the difference was significant(P<0.05). The observation group was significantly higher total efficiency, the difference was significant (P <0.05). Conclusions Insulin glargine treatment of type 2 diabetes, repaglinide combined to give effective control of blood glucose, significantly improved β-cell function and insulin sensitivity.
【Key words 】Type 2 diabetes glargine repaglinide
糖尿病(diabetes)是由遗传因素及免疫功能紊乱、精神因素等各种致病因子作用于机体导致胰岛功能减退、胰岛素抵抗等而引发的一系列代谢紊乱综合征。长期的高血糖可引起微血管、大血管及神经病变，导致心、肾、脑等器官的功能衰退、衰竭甚至死亡。临床只有良好的血糖控制，才可以预防或者延缓糖尿病及其并发症的发生。我院2009年1月-2010年1月采用甘精胰岛素联合瑞格列奈治疗2型糖尿病35例，效果较好，现将治疗情况报道如下：
1 资料与方法
1.1 一般资料 选择我院2009年1月-2010年1月新入院确诊的2型糖尿病患者共70例作为观察对象 ......
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