调脂治疗对高脂血症合并糖耐量异常的临床疗效观察(1)
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【摘要】目的 观察不同调脂治疗方案对高脂血症合并糖耐量异常的疗效及安全性.方法 将157例高脂血症合并糖耐量异常的患者随机分为三组，即血脂康组，辛伐他汀组和生活方式干预组(对照组)，治疗6个月后观察疗效。结果 血脂康组及辛伐他汀组治疗6个月后TC、TG、LDL-C水平与治疗前对比有显著性降低，HDL-C显著升高(P<0.01)，而对照组TC、TG、LDL-C水平治疗后仅有轻度降低，HDL-C轻度升高(P>0.05)。血脂康组FPG、2hPG及HbAIc与治疗前相比差异有统计学意义(P<0.05)；辛伐他汀组和对照组FPG、2hPG及HbAIc与治疗前相比差异无统计学意义(P>0.05)。结论 血脂康更适合高脂血症合并糖耐量异常患者，能有效降低高脂血症及改善糖耐量异常，且安全性良好，值得在临床推广。
【关键词】调脂治疗 高脂血症糖耐量异常
中图分类号：R589.21 文献标识码：A 文章编号：1005-0515(2011)7-054-03
Clinical observation on lipid-regulating treatment for patients with hyperlipemia and impaired glucose tolerance
XIE Yuanling1 ZHOU Zhiheng2 HUANG Yanping1
(1. General practice department , the second people,s hospital of Yuexie District , Guangzhou 510180,China.
2. School of public health and general practice , Guangzhou medical college . Guangzhou 510000 China.)
【Abstract】Objective The study was conducted to investigate the clinical efficacy and safety of different ways of lipid-modulating treatment for patients with hyperlipemia and impaired glucose tolerance. Method 157 cases of patients with hyperlipemia and impaired glucose tolerance were randomly allocated to xuezhikang group , simvastatin group and lifestyle intervention group respectively . the therapeutic results were tested 6 months after treatment. Results After 6 months treatment , the lipid profile was evidently improved in xuezhikang group and simvastatin group . level of total cholesterol ( TC ), triglyceridemia ( TG ) , low-density lipoprotein cholesterol ( LDL-C ) were significantly reduced and high-density lipoprotein cholesterol ( HDL-C ) increased significantly (P<0.01). Slightly change of above indicators were found in control group (P>0.05). The level of fasting plasma glucose ( FPG ) , 2 hours plasma glucose ( 2hPG ) and glycohemoglobin ( HbAIc ) decreased obviously in xuezhikang group (P<0.05), while there were no obviously change of above-mentioned indices in both simvastatin group and lifestyle intervention group ( P>0 ......
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