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异丙酚复合芬太尼用于无痛人工流产术的临床观察(1)
http://www.100md.com 2010年5月1日 《中国健康月刊》 20105
     【摘要】 目的 观察芬太尼、异丙酚用于人工流产麻醉的效果。方法 选择我院2005年—2009年自愿采用异丙酚复合芬太尼麻醉进行人工流产术300例,ASAⅠ-Ⅱ级,年龄19-42岁,体重45-78kg,并且均无心、肺疾患,无高血压,无药物过敏史。病人麻醉诱导前常规持续鼻导管吸氧2--5L/min,用普通的5号头皮针静脉穿刺,缓慢推注芬太尼1ug/kg,后以异丙酚1.5-2ug/kg缓慢推注诱导麻醉,待病人意识消失,睫毛反射消失后开始手术,术中出现不自主肢体活动时给予异丙酚0.5m/kg追加。术后病人5min内清醒,观察20-30min无异常离院。结果 生命体征监测:注药初期出现短暂的呼吸、循环抑制,SBP、DBP 、MAP、HR、SpO2下降明显,但均在2-3min内恢复正常,本组300例中16例(5.3%)的病人出现一过性的呼吸抑制,持续时间短暂多能自行恢复,仅有2例出现舌后缀,经提下颌并加大氧流量后呼吸恢复正常,术中出血无明显增多,术后宫缩良好。23例术后轻微头晕,休息后好转。结论 芬太尼、异丙酚用于人工流产麻醉安全,可靠。
, http://www.100md.com
    【关键词】 异丙酚;芬太尼;人工流产

    【中图分类号】R719.3+1【文献标识码】 B 【文章编号】1005-0515(2010)005-006-03

    【Abstract】 ObjectiveTo observe the effect of Propofol and Fentanyl during induced abortion. Methods 300 cases of pregnant women were involved, voluntarily provided with propofol and fentanyl during induced abortion in the years 2005-2009 in our hospital, and considered to have I or II level of surgery with ages varying from 19 to 42 and weight varying from 45 to 78 kg. All of them were free of heart and lung diseases, hypertension and drug allergy. Conventionally, patients breathed in oxygen 2--5L/min by nasal cannula and were injected fentanyl slowly with the normal model 5 scalp needle punctured in the venipuncture before the anesthesia induction. After that, 1.5-2ug/kg propofol was injected slowly to induct anesthesia. The operation began when the patients were unconscious and their eyelash reflection disappeared as well. 0.5m/kg propofol could be additive if patients showed physical activities unconsciously during the operation. After the operations, patients awoke within 5 minutes and departed from the hospital when no abnormalities occurred within 20-30min’ observation. ResultsThe monitoring results of vital signs: patients showed temporary restrain of breath and circulation; meanwhile, SBP、DBP 、MAP、HR、SpO2 also decreased significantly during the first period, but all of these returned to normal within 2-3min. 16 cases out of 300 (5.3%), temporary restrain of breath happened to patients, but the lasting time was short and most patients recovered automatically. Only 2 cases had falling tongues and patients’ breath returned to normal after their lower jaws were lifted and more oxygen was given. There was no more blood apparently during the operation and uterine contractions were quite good. 23 cases were slightly dizzy and then improved after having a rest. Conclusion The application of propofol and fentanyl during induced abortion is safe and reliable.
, 百拇医药
    [key words] Propofol, Fentanyl, Induced Abortion

    异丙酚近年来已广泛应用于人工流产的麻醉。它具有起效快,时效短,苏醒迅速,完全平稳,对呼吸,循环影响轻微等优点,停药后数分钟就可完全清醒,几乎无蓄积作用,镇静效果好。但其镇痛作用较弱。而麻醉性镇痛药芬太尼镇痛效果好,具有满意的镇痛效果,我院采用异丙酚与芬太尼复合麻醉用于人工流产术取得满意的临床效果,现就其对病人的麻醉效果、呼吸和循环系统的影响分析如下:

    1资料与方法

    1.1 一般资料选择我院2005年—2009年自愿采用异丙酚复合芬太尼麻醉进行人工流产术300例,ASAⅠ-Ⅱ级,年龄19-42岁,体重45-78kg。妊娠50-70d,经妇科检查,尿妊娠试验阳性,B超检查证实宫内妊娠。并且均无心、肺疾患,无高血压,无药物过敏史。

    1.2 麻醉方法麻醉前禁饮食12h,未用术前药。术中采用多参数麻醉监护仪,监测病人收缩压(SBP)、舒张压(DBP)、平均动脉压(MAP)、心电图(EKG)和血氧饱和度(SpO2)。评估麻醉效果优:指手术期间无肢体活动;良:指手术期间有不影响操作的肢体活动;差:指手术期间肢体乱动,手术无法进行。病人麻醉诱导前常规持续鼻导管吸氧2--5L/min,用普通的5号头皮针静脉穿刺,缓慢推注芬太尼1ug/kg,后以异丙酚1.5-2ug/kg缓慢推注诱导麻醉,待病人意识消失,睫毛反射消失后开始手术,术中出现不自主肢体活动时给予异丙酚0.5m/kg追加。术后病人5min内清醒,观察20-30min无异常离院。, 百拇医药(巴维东)
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