复方甘草酸苷对患儿急性过敏性紫癜免疫功能的影响(1)
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【摘要】目的:探讨复方甘草酸苷对急性过敏性紫癜( HSP)免疫功能的调节作用。方法:将88例HSP患儿按1∶1分为观察组和对照组两组 , 两组均常规治疗，观察组加用复方甘草酸苷，观察两组治疗后疗效 , 治疗前后分别采用双抗体夹心酶联免疫吸附实验( EL ISA)检测外周血清 IL - 4与 IFN -γ水平;并用同样方法检测 30 例健康对照组。结果:观察组疗效优于对照组 ,复发率低于对照组; IFN -γ水平较健康对照组显著降低( P < 0.01) , 复方甘草酸苷治疗组患儿治疗后血清 IL - 4 水平显著降低( P < 0.01) ,而 IFN - r水平显著增加( P < 0.01) 。常规治疗组治疗前后水平无显著差异( P > 0.05) 。结论 复方甘草酸苷能调节过敏性紫癜患儿 Th1/ Th2 细胞因子的失衡状态 ,改善患儿机体免疫功能紊乱状态 ,对患者治疗有著意义。
【关键词】过敏性紫癜; 复方甘草酸苷; Th1/ Th2
Glycyrrhizin in children with acute Henoch-Schonlein purpura on the immune function of
【Abstract】 Objective: Of glycyrrhizin on acute allergic purpura (HSP) regulation of immune function. Methods: 88 cases of children with HSP 1:1 observation group and control group were divided into two groups, conventional treatment in both groups, observation group were treated with glycyrrhizin, after treatment effects were observed before and after treatment were double antibody sandwich enzyme linked immunosorbent assay (EL ISA) detection in peripheral blood IL - 4 and IFN-γ levels; and using the same method of detection of 30 healthy control group. Results: Clinical observation group than the control group, the recurrence rate is lower than the control group; IFN-γ levels than healthy control group decreased significantly (P <0.01), glycyrrhizin treated group after treatment in children with serum IL - 4 was significantly lower (P <0.01), while IFN - r was significantly increased (P <0.01). Before and after conventional treatment group no significant difference (P> 0.05). Conclusion: Glycyrrhizin in children with Henoch-Schonlein purpura can regulate the Th1 / Th2 cytokine imbalance and improve the status of children with immune disorders, and patients have a meaning.
【Key words】Henoch-Schonlein purpura; glycyrrhizin; Th1/ Th2
【中图分类号】R4535【文献标识码】B【文章编号】1005-0515(2011)03-0015-02
过敏性紫癜(HSP)的发病机制至今未明 ,但它属于自身免疫介导的全身性血管炎已为多数学者公认。现在有的学者人为 ,HSP患儿存在 T淋巴细胞功能紊乱 ,发现 Th2 细胞功能亢进 ,Th1 受抑制 , Th1/ Th2 平衡状态功能失衡[1]。中药复方甘草酸苷具有重要的调节机体体液和细胞免疫功能的生物学效应。本研究采用复方甘草酸苷注射液治疗 HSP 患儿前后对 Th1/ Th2 细胞因子水平的影响 ,为 HSP 的治疗提供一个新的方法。
1 资料与方法
1.1 临床资料:病例为2005年7月至2008年12月收治的过敏性紫癜患儿共88例，男51例 ，女37例，年龄 5 .3 岁， 均符合1990年美国风湿病协会制定的 AP诊断标准 ，病例以皮肤病变为主 单纯型 58例 肾型 12 例 其余为混合型 将 88例随机分成观察组和治疗组 每组44例 ......
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