糖前平颗粒治疗糖尿病前期人群临床研究(1)
摘要：目的 觀察糖前平颗粒治疗糖尿病前期人群的临床疗效。方法 采用随机数字表法将140例糖尿病前期患者分为治疗组和对照组各70例。2组均行饮食、运动等生活方式干预及健康宣教。对照组予盐酸二甲双胍肠溶片，每次0.25 g，每日3次，口服。治疗组在对照组基础上予糖前平颗粒，每日1剂，每日2次，口服。均连续治疗3个月。评价2组临床疗效，观察中医症状积分，血糖、血脂水平及转归。结果 治疗组总有效率为89.9%(62/69)，对照组为58.8%(40/68)，治疗组优于对照组，差异有统计学意义(P<0.05)。与本组治疗前比较，2组治疗后中医症状积分明显降低，差异有统计学意义(P<0.05)；2组治疗后比较，治疗组中医症状积分低于对照组，差异有统计学意义(P<0.05)。与本组治疗前比较，2组治疗后空腹血糖(FBG)、糖化血红蛋白(HbA1c)、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)及空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)明显降低，差异有统计学意义(P<0.05)；2组治疗后比较，治疗组FBG、TC水平低于对照组，差异有统计学意义(P<0.05)。治疗组治疗后糖尿病前期逆转率、糖尿病新发率优于对照组(P<0.05)。结论 糖前平颗粒干预糖尿病前期患者疗效显著，可有效预防糖尿病发生。
关键词：糖尿病前期；糖前平颗粒；临床疗效
DOI：10.3969/j.issn.1005-5304.2018.09.007
中图分类号：R259.871 文献标识码：A 文章编号：1005-5304(2018)09-0026-05
Abstracts： Objective To observe the clinical efficacy of Tangqianping Granules in the treatment for patients with pre-diabetes. Methods Totally 140 patients with pre-diabetes were divided into treatment group and control group through random number table method， with 70 cases in each group. Both groups had lifestyle intervention and health education， such as diet and exercise. The control group was treated with metformin hydrochloride enteric-coated tablets， 0.25 g per time， three times a day， orally. The treatment group was treated with Tangqianping Granules on the basis of the control group， one dosage per day， twice a day， orally. The treatment course for both groups were 3 months. Clinical efficacy of both groups were evaluated. TCM symptom scores， blood glucose， lipid level and prognosis were observed. Results The total effective rate was 89.9% (62/69) in the treatment group and 58.8% (40/68) in the control group， and the treatment group was better than the control group， with statistical significance (P<0.05). Compared with before treatment， TCM symptom scores of the two groups after treatment were significantly lower， with statistical significance (P<0.05). After treatment， TCM symptom scores in the treatment group were lower than those in the control group， with statistical significance (P<0.05). Compared with before treatment， fasting blood glucose (FBG)， glycosylated hemoglobin (HbA1c)， total cholesterol (TC)， triglyceride (TG)， low-density lipoprotein cholesterol (LDL-C)， fasting insulin (FINS)， and insulin resistance index (HOMA-IR) decreased after treatment in both groups， with statistical significance (P<0.05). After treatment， the levels of FBG and TC in the treatment group were lower than those in the control group， with statistical significance (P<0.05). The rate of reversal of pre-diabetes and the incidence of new diabetes after treatment in the treatment group were better than those in the control group (P<0.05). Conclusion Intervention of Tangqianping Granules in the pre-diabetic population has significant clinical efficacy， which can effectively prevent the occurrence of diabetes., 百拇医药(王兴涌 许美玲)
关键词：糖尿病前期；糖前平颗粒；临床疗效
DOI：10.3969/j.issn.1005-5304.2018.09.007
中图分类号：R259.871 文献标识码：A 文章编号：1005-5304(2018)09-0026-05
Abstracts： Objective To observe the clinical efficacy of Tangqianping Granules in the treatment for patients with pre-diabetes. Methods Totally 140 patients with pre-diabetes were divided into treatment group and control group through random number table method， with 70 cases in each group. Both groups had lifestyle intervention and health education， such as diet and exercise. The control group was treated with metformin hydrochloride enteric-coated tablets， 0.25 g per time， three times a day， orally. The treatment group was treated with Tangqianping Granules on the basis of the control group， one dosage per day， twice a day， orally. The treatment course for both groups were 3 months. Clinical efficacy of both groups were evaluated. TCM symptom scores， blood glucose， lipid level and prognosis were observed. Results The total effective rate was 89.9% (62/69) in the treatment group and 58.8% (40/68) in the control group， and the treatment group was better than the control group， with statistical significance (P<0.05). Compared with before treatment， TCM symptom scores of the two groups after treatment were significantly lower， with statistical significance (P<0.05). After treatment， TCM symptom scores in the treatment group were lower than those in the control group， with statistical significance (P<0.05). Compared with before treatment， fasting blood glucose (FBG)， glycosylated hemoglobin (HbA1c)， total cholesterol (TC)， triglyceride (TG)， low-density lipoprotein cholesterol (LDL-C)， fasting insulin (FINS)， and insulin resistance index (HOMA-IR) decreased after treatment in both groups， with statistical significance (P<0.05). After treatment， the levels of FBG and TC in the treatment group were lower than those in the control group， with statistical significance (P<0.05). The rate of reversal of pre-diabetes and the incidence of new diabetes after treatment in the treatment group were better than those in the control group (P<0.05). Conclusion Intervention of Tangqianping Granules in the pre-diabetic population has significant clinical efficacy， which can effectively prevent the occurrence of diabetes., 百拇医药(王兴涌 许美玲)