第二代整合酶链转移抑制剂dolutegravir(4)
Hightower KE， Wang R， Deanda F， et al. Dolutegravir (S/GSK1349572) exhibits significantly slower dissociation than raltegravir and elvitegravir from wild-type and integrase inhibitor-resistant HIV-1 integrase-DNA complexes [J]. Antimicrob Agents Chemother， 2011， 55(10)： 4552-4559.Garrido C， Soriano V， Geretti AM， et al. Resistance associated mutations to dolutegravir (S/GSK1349572) in HIV infected patients — impact of HIV subtypes and prior raltegravir experience [J]. Antiviral Res ......
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