降纤酶治疗急性脑梗死的短期效果及对血浆纤维蛋白原的影响(1)
摘 要 目的：探讨降纤酶治疗急性脑梗死的短期效果及对血浆纤维蛋白原的影响。方法：收集2012年5月—2015年3月收治的84例急性脑梗死患者，均采用脑康复、脑复素等药物治疗，将患者随机分为试验组42例，同时给予降纤酶治疗；对照组42例，同时给予安慰剂治疗。观察患者疗效、神经功能缺损评分、血浆纤维蛋白原水平和凝血功能变化情况。结果：试验组总有效率为95.24%(40/42)，高于对照组的73.81%(31/42，P<0.05)。治疗后，试验组神经功能缺损评分、血浆纤维蛋白原水平均低于对照组和治疗前(P<0.05)，但两组患者治疗前后的凝血功能无明显变化。试验组不良反应发生率为9.52%(4/42)，低于对照组的26.19%(11/42，P<0.05)。结论：降纤酶治疗急性脑梗死的短期效果较好，而且能改善患者神经功能缺损评分和血浆纤维蛋白原水平，对凝血功能无明显影响。
关键词 急性脑梗死 降纤酶 短期效果 血浆纤维蛋白原
中图分类号：R743.3 文献标志码：A 文章编号：1006-1533(2016)22-0022-02
Short term effect of defibrase in the treatment of acute cerebral infarction and its effect on plasma fibrinogen
CHEN Shulan， ZHANG Guoping， CHEN Jian(People’s Hospital of Luxi County， Pingxiang City， Jiangxi 337200， China)
ABSTRACT Objective： To investigate the short term effect of defibrase in the treatment of acute cerebral infarction and its effect of plasma fibrinogen. Methods： Eighty-four cases of acute cerebral infarction treated with brain rehabilitation， cerebrolysin and other drugs in the hospital from May 2012 to March 2015 were collected and divided into an experiment group with 42 cases who were treated with defibrase and a control group with 42 cases treated by placebo. The curative effect， the nerve function defect score， the plasma fibrinogen level and the blood coagulation function change were observed in the patients. Results： The total effective rate of the experiment group was 95.24%(40/42)，which was higher than that of the control group 73.81%(31/42， P<0.05). After treatment， the nerve function defect score and plasma fibrinogen level of the experiment group were lower than those of the control group and before treatment(P<0.05)， but there was no significant change of coagulation function in the two groups before and after treatment. The incidence of adverse reactions in the experiment group was 9.52%(4/42)， which was lower than that in the control group 26.19%(11/42， P<0.05). Conclusion： The short term effect of the defibrase in the treatment of acute cerebral infarction is better. It can improve the neurological function defect score and plasma fibrinogen level， but it has no significant effect on coagulation function.
KEY WORDS acute cerebral infarction； defibrase； short term effect； plasma fibrinogen
随着老龄化社会的到来，老年急性脑梗死的发病率不断增加。研究有效的治疗措施，改善急性脑梗死患者的生活质量，有重要意义[1]。临床治疗急性脑梗死主要是恢复患者的神经功能，改善凝血状态。本文报道降纤酶治疗急性脑梗死的短期效果及对血浆纤维蛋白原的影响。
1 资料与方法
1.1 一般资料
收集2012年5月至2015年3月我院收治的急性脑梗死患者84例，均经CT或MRI确诊，按入院顺序抽签后随机分为试验组和对照组各42例。试验组男28例，女14例，年龄50～74岁，平均(62.35±5.74)岁；对照组男27例，女15例，年龄51～74岁，平均(63.11±6.27)岁。两组患者一般资料相比差异无计学意义(P>0.05)。患者均签署知情同意协议书。排除严重高血压和有明显出血倾向者。 (陈淑兰 张国平 谌建)
关键词 急性脑梗死 降纤酶 短期效果 血浆纤维蛋白原
中图分类号：R743.3 文献标志码：A 文章编号：1006-1533(2016)22-0022-02
Short term effect of defibrase in the treatment of acute cerebral infarction and its effect on plasma fibrinogen
CHEN Shulan， ZHANG Guoping， CHEN Jian(People’s Hospital of Luxi County， Pingxiang City， Jiangxi 337200， China)
ABSTRACT Objective： To investigate the short term effect of defibrase in the treatment of acute cerebral infarction and its effect of plasma fibrinogen. Methods： Eighty-four cases of acute cerebral infarction treated with brain rehabilitation， cerebrolysin and other drugs in the hospital from May 2012 to March 2015 were collected and divided into an experiment group with 42 cases who were treated with defibrase and a control group with 42 cases treated by placebo. The curative effect， the nerve function defect score， the plasma fibrinogen level and the blood coagulation function change were observed in the patients. Results： The total effective rate of the experiment group was 95.24%(40/42)，which was higher than that of the control group 73.81%(31/42， P<0.05). After treatment， the nerve function defect score and plasma fibrinogen level of the experiment group were lower than those of the control group and before treatment(P<0.05)， but there was no significant change of coagulation function in the two groups before and after treatment. The incidence of adverse reactions in the experiment group was 9.52%(4/42)， which was lower than that in the control group 26.19%(11/42， P<0.05). Conclusion： The short term effect of the defibrase in the treatment of acute cerebral infarction is better. It can improve the neurological function defect score and plasma fibrinogen level， but it has no significant effect on coagulation function.
KEY WORDS acute cerebral infarction； defibrase； short term effect； plasma fibrinogen
随着老龄化社会的到来，老年急性脑梗死的发病率不断增加。研究有效的治疗措施，改善急性脑梗死患者的生活质量，有重要意义[1]。临床治疗急性脑梗死主要是恢复患者的神经功能，改善凝血状态。本文报道降纤酶治疗急性脑梗死的短期效果及对血浆纤维蛋白原的影响。
1 资料与方法
1.1 一般资料
收集2012年5月至2015年3月我院收治的急性脑梗死患者84例，均经CT或MRI确诊，按入院顺序抽签后随机分为试验组和对照组各42例。试验组男28例，女14例，年龄50～74岁，平均(62.35±5.74)岁；对照组男27例，女15例，年龄51～74岁，平均(63.11±6.27)岁。两组患者一般资料相比差异无计学意义(P>0.05)。患者均签署知情同意协议书。排除严重高血压和有明显出血倾向者。 (陈淑兰 张国平 谌建)