硒化物—期待开发的含硒表观靶向抗癌药物(1)
摘 要 硒对表观遗传修饰异常会产生干预影响，阻遏肿瘤的发生和转移。硒化物是肿瘤特异性表观标志物抑制剂，是期待开发的新型含硒表观靶向抗癌药物。关键词 硒 表观遗传修饰 表观标志物抑制剂 抗癌药 开发
中图分类号：R979.1 文献标识码：A 文章编号：1006-1533(2017)03-0075-04
Selenium compounds — looking forward to be developed as epigenetic targeting selenium-containing anti-tumor drugs*
ZHU Huiqiu1**， HUA Yan1， WANG Mingli2***
(1. Anhui Huaxin Pharmaceutical Co. Ltd.， Hefei 230000， China； 2. Anhui Medical University， HeFei 230032， China)
ABSTRACT Selenium compounds can produce an intervention effect on the abnormality of epigenetic modification and then repress the occurrence and metastasis of tumor. They can be used as the inhibitors of some tumor specific epigenetic markers and expected to be developed as a new type of epigenetic targeting selenium-containing anti-tumor drugs.
KEy WORDS selenium； epigenetic modification； inhibitors of epigenetic markers； anti-cancer drugs； development
硒最重要的生物学功能是抗癌 ......
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