化疗联合深部热疗对乳腺癌协同抗肿瘤效应分析(1)
摘 要 目的：探讨化疗联合深部热疗对乳腺癌患者的协同治疗效果。方法：选取我院2015年1月至2016年12月期间收治的60例乳腺癌患者，随机分为观察组和对照组各30例，对照组仅实施化疗，观察组使用化疗方案+深部热疗治疗。比较两组患者的临床疗效和不良反应，采用卡氏功能 (KPS)量表对生活质量进行评定。结果：观察组客观缓解率明显高于对照组(P<0.05)，而两组间不良反应发生率差异不显著(P>0.05)；观察组治疗后的生活质量优于对照组和治疗前(P<0.05)。结论：化疗联合深部热疗治疗乳腺癌患者的近期疗效确切，不增加毒副作用，且提高患者生活质量，具有一定的协同抗肿瘤效果。
关键词 深部热疗 化疗 乳腺癌 临床疗效
中图分类号：R737.9； R730.59 文献标识码：B 文章编号：1006-1533(2017)09-0030-03
Synergistic anti-tumor effect of chemotherapy combined with deep hyperthermia on breast cancer
LIAO Yayong*， MA Rui， YAO Jine
(The People’s Hospital of Jiangmen City， Guangdong 529020， China)
ABSTRACT Objective： to study the synergy effect of chemotherapy combined with deep thermal therapy for the treatment of patients with breast cancer. Methods： Sixty cases of patients with breast cancer in our hospital from January 2015 to December 2016 were randomly divided into an observation group and a control group with 30 cases each. All the patients were treated by chemotherapy and the observation group was additionally treated by deep hyperthermia. The clinical efficacy and adverse reactions were compared between the two groups and the quality of life was assessed by KPS scale. Results： The objective remission rate was significantly higher in the observation group than in the control group (P<0.05)， and the incidence of adverse reactions in both groups showed no significant differences (P>0.05). The quality of life in the observation group was better than that in the control group and before treatment (P<0.05). Conclusion： Recent curative effect of chemotherapy combined with deep hyperthermia on the treatment of patients with breast cancer is exact without the increase of adverse reactions， and it can help improve the quality of life of patients after treatment with certain synergistic anti-tumor effect.
KEy WORDS deep hyperthermia； chemotherapy； breast cancer； clinical curative effect
乳腺癌是女性最常見的恶性肿瘤之一，发病率较高，仅次于子宫癌，且近年来呈年轻化的发展趋势，给患者的生理和心理均带来了严重的影响[1-3]。在临床中，针对乳腺癌疾病的治疗多采用手术、放化疗以及靶向治疗等措施，均对改善患者的疾病起到了一定的效果。其中，化疗可以控制微小病灶，防止乳腺癌的转移和复发。尽管该方法对癌细胞的杀伤作用大，但依然对患者的身体造成了很大损伤。患者在接受化疗后可能会出现身体虚弱、造血和免疫等功能紊乱，毒副作用大，致使患者常难以耐受，进而加重病情[4-6]。因而目前强调多学科综合治疗模式。我院通过对收治的乳腺癌患者实施化疗联合深部热疗进行治疗，取得了良好的治疗效果。
1 资料与方法
1.1 一般资料
选取我院2016年1月至2016年12月期间收治的60例乳腺癌患者作为本研究对象。纳入标准[7-8]：①所有患者均经相关诊断和病理学明确诊断为乳腺癌；②预计生存期在6个月以上；③对本次研究知情同意，同时排除以往有化疗史、合并患有其他心、肾和肺等严重疾病患者。将符合标准的患者随机分为观察组和对照组各30例，其中观察组患者的年龄为39～58岁，平均年龄(47.7±9.2)岁，平均病程(2.0±0.7)年，浸润性导管癌11例，浸润性小叶癌7例，单纯癌6例，其它类型癌6例；临床分期：Ⅰ期2例、Ⅱ期12例、Ⅲ期16例；对照组患者的年龄为39～58岁，平均年龄(45.3±8.6)岁，平均病程(1.6±0.6)年，浸润性导管癌6例，浸润性小叶癌12例，单纯癌6例，其它类型癌6例；临床分期：Ⅰ期3例、Ⅱ期10例、Ⅲ期17例。经比较，两组患者的平均年龄、病程以及肿瘤分期等配对因素无统计学差异(P>0.05)。 (廖亚勇 马蕊 姚金娥)
关键词 深部热疗 化疗 乳腺癌 临床疗效
中图分类号：R737.9； R730.59 文献标识码：B 文章编号：1006-1533(2017)09-0030-03
Synergistic anti-tumor effect of chemotherapy combined with deep hyperthermia on breast cancer
LIAO Yayong*， MA Rui， YAO Jine
(The People’s Hospital of Jiangmen City， Guangdong 529020， China)
ABSTRACT Objective： to study the synergy effect of chemotherapy combined with deep thermal therapy for the treatment of patients with breast cancer. Methods： Sixty cases of patients with breast cancer in our hospital from January 2015 to December 2016 were randomly divided into an observation group and a control group with 30 cases each. All the patients were treated by chemotherapy and the observation group was additionally treated by deep hyperthermia. The clinical efficacy and adverse reactions were compared between the two groups and the quality of life was assessed by KPS scale. Results： The objective remission rate was significantly higher in the observation group than in the control group (P<0.05)， and the incidence of adverse reactions in both groups showed no significant differences (P>0.05). The quality of life in the observation group was better than that in the control group and before treatment (P<0.05). Conclusion： Recent curative effect of chemotherapy combined with deep hyperthermia on the treatment of patients with breast cancer is exact without the increase of adverse reactions， and it can help improve the quality of life of patients after treatment with certain synergistic anti-tumor effect.
KEy WORDS deep hyperthermia； chemotherapy； breast cancer； clinical curative effect
乳腺癌是女性最常見的恶性肿瘤之一，发病率较高，仅次于子宫癌，且近年来呈年轻化的发展趋势，给患者的生理和心理均带来了严重的影响[1-3]。在临床中，针对乳腺癌疾病的治疗多采用手术、放化疗以及靶向治疗等措施，均对改善患者的疾病起到了一定的效果。其中，化疗可以控制微小病灶，防止乳腺癌的转移和复发。尽管该方法对癌细胞的杀伤作用大，但依然对患者的身体造成了很大损伤。患者在接受化疗后可能会出现身体虚弱、造血和免疫等功能紊乱，毒副作用大，致使患者常难以耐受，进而加重病情[4-6]。因而目前强调多学科综合治疗模式。我院通过对收治的乳腺癌患者实施化疗联合深部热疗进行治疗，取得了良好的治疗效果。
1 资料与方法
1.1 一般资料
选取我院2016年1月至2016年12月期间收治的60例乳腺癌患者作为本研究对象。纳入标准[7-8]：①所有患者均经相关诊断和病理学明确诊断为乳腺癌；②预计生存期在6个月以上；③对本次研究知情同意，同时排除以往有化疗史、合并患有其他心、肾和肺等严重疾病患者。将符合标准的患者随机分为观察组和对照组各30例，其中观察组患者的年龄为39～58岁，平均年龄(47.7±9.2)岁，平均病程(2.0±0.7)年，浸润性导管癌11例，浸润性小叶癌7例，单纯癌6例，其它类型癌6例；临床分期：Ⅰ期2例、Ⅱ期12例、Ⅲ期16例；对照组患者的年龄为39～58岁，平均年龄(45.3±8.6)岁，平均病程(1.6±0.6)年，浸润性导管癌6例，浸润性小叶癌12例，单纯癌6例，其它类型癌6例；临床分期：Ⅰ期3例、Ⅱ期10例、Ⅲ期17例。经比较，两组患者的平均年龄、病程以及肿瘤分期等配对因素无统计学差异(P>0.05)。 (廖亚勇 马蕊 姚金娥)