美托洛尔联合曲美他嗪治疗老年冠心病合并心力衰竭效果(1)
摘 要 目的：探讨美托洛尔联合曲美他嗪治疗老年冠心病合并心力衰竭的效果。方法：收集2018年4月—2019年2月诊治的老年冠心病患者60例，分为对照组和观察组各30例。对照组口服美托洛尔6.25 mg/d，逐步增加至50 mg/次，2次/d，治疗3个月。观察组口服美托洛尔，曲美他嗪20 mg/次，3次/d，治疗3个月。观察两组心功能参数[左室射血分数(LVEF)、左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)]、6 min步行距离和炎症因子变化情况。结果：观察组干预后LVEF、6 min步行距离较高，LVESD、LVEDD较低，与对照组比差异有统计学意义(P<0.05)；炎症因子水平亦低于对照组(P<0.05)。结论：对于老年冠心病合并心力衰竭患者，采取美托洛尔联合曲美他嗪治疗，可以获得较好的预后。
关键词 冠心病；心力衰竭；美托洛尔；曲美他嗪；效果
中图分类号：R541.6 文獻标志码：A 文章编号：1006-1533(2020)08-0033-02
Efficacy of metoprolol combined with trimetazidine in the treatment of senile coronary heart disease with heart failure
WU Junbang
(Department of Geriatrics of Kangning Hospital， Nanchang， Jiangxi 330103， China)
ABSTRACT Objective： To investigate the effect of metoprolol combined with trimetazidine in the treatment of senile coronary heart disease with heart failure. Methods： Sixty cases of senile coronary heart disease diagnosed and treated from April 2018 to February 2019 were collected， and divided into a control group and an observation group with 30 cases in each group. The control group took metoprolol 6.25 mg /d， which gradually increased to 50 mg / time， 2 times /d， and the treatment was for 3 months. The observation group was orally administered metoprolol and trimetazidine 20 mg / time， 3 times /d and the treatment was for 3 months. The cardiac function parameters [left ventricular ejection fraction (LVEF)， left ventricular enddiastolic diameter (LVEDD)， and left ventricular end-systolic diameter (LVESD)]， 6-minute walking distance， and changes in inflammatory factors were observed in the two groups. Results： After intervention， the observation group had higher LVEF and 6-minute walking distance， and lower LVESD and LVEDD， and the difference was statistically significant compared with the control group (P <0.05)； the levels of inflammatory factors in the observation group were lower than those in the control group(P < 0.05). Conclusion： For senile coronary heart disease patients with heart failure， metoprolol combined with trimetazidine can obtain a better prognosis.
KEY WORDS coronary heart disease； heart failure； metoprolol； trimetazidine； effect
冠状动脉粥样硬化性心脏病(CHD)临床较常见[1]，会造成患者心肌缺氧、心脏受损等情况，严重者引发心力衰竭，危及患者生命[2-3]，积极的治疗十分必要。本文报道美托洛尔联合曲美他嗪治疗CHD的疗效。
1 资料与方法
1.1 一般资料
收集2018年4月—2019年2月康宁医院老年医学科诊治的CHD患者60例，分为对照组和观察组各30例。观察组男19例，女11例，年龄60～78岁，平均(68.46±8.79)岁；病程2～7年，平均(4.22±0.74)年；NYHA心功能分级Ⅱ级12例，Ⅲ级11例，Ⅳ级7例。对照组男18例，女12例，年龄60～79岁，平均(68.97±8.12)岁；病程2～8年，平均(4.35±0.88)年；NYHA心功能分级Ⅱ级13例，Ⅲ级11例，Ⅳ级6例。两组患者的一般资料具可比(P>0.05)。, 百拇医药(吴军榜)
关键词 冠心病；心力衰竭；美托洛尔；曲美他嗪；效果
中图分类号：R541.6 文獻标志码：A 文章编号：1006-1533(2020)08-0033-02
Efficacy of metoprolol combined with trimetazidine in the treatment of senile coronary heart disease with heart failure
WU Junbang
(Department of Geriatrics of Kangning Hospital， Nanchang， Jiangxi 330103， China)
ABSTRACT Objective： To investigate the effect of metoprolol combined with trimetazidine in the treatment of senile coronary heart disease with heart failure. Methods： Sixty cases of senile coronary heart disease diagnosed and treated from April 2018 to February 2019 were collected， and divided into a control group and an observation group with 30 cases in each group. The control group took metoprolol 6.25 mg /d， which gradually increased to 50 mg / time， 2 times /d， and the treatment was for 3 months. The observation group was orally administered metoprolol and trimetazidine 20 mg / time， 3 times /d and the treatment was for 3 months. The cardiac function parameters [left ventricular ejection fraction (LVEF)， left ventricular enddiastolic diameter (LVEDD)， and left ventricular end-systolic diameter (LVESD)]， 6-minute walking distance， and changes in inflammatory factors were observed in the two groups. Results： After intervention， the observation group had higher LVEF and 6-minute walking distance， and lower LVESD and LVEDD， and the difference was statistically significant compared with the control group (P <0.05)； the levels of inflammatory factors in the observation group were lower than those in the control group(P < 0.05). Conclusion： For senile coronary heart disease patients with heart failure， metoprolol combined with trimetazidine can obtain a better prognosis.
KEY WORDS coronary heart disease； heart failure； metoprolol； trimetazidine； effect
冠状动脉粥样硬化性心脏病(CHD)临床较常见[1]，会造成患者心肌缺氧、心脏受损等情况，严重者引发心力衰竭，危及患者生命[2-3]，积极的治疗十分必要。本文报道美托洛尔联合曲美他嗪治疗CHD的疗效。
1 资料与方法
1.1 一般资料
收集2018年4月—2019年2月康宁医院老年医学科诊治的CHD患者60例，分为对照组和观察组各30例。观察组男19例，女11例，年龄60～78岁，平均(68.46±8.79)岁；病程2～7年，平均(4.22±0.74)年；NYHA心功能分级Ⅱ级12例，Ⅲ级11例，Ⅳ级7例。对照组男18例，女12例，年龄60～79岁，平均(68.97±8.12)岁；病程2～8年，平均(4.35±0.88)年；NYHA心功能分级Ⅱ级13例，Ⅲ级11例，Ⅳ级6例。两组患者的一般资料具可比(P>0.05)。, 百拇医药(吴军榜)
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