【摘要】目的：探讨国产利培酮在治疗精神分裂症的疗效、安全性及经济性。方法：对120例门诊或住院精神分裂症患者使用国产利培酮治疗6周，分别于治疗前后进行阳性和阴性症状量表(PANSS)测查。结果：治疗第一周末，PANSS总分及分量表分与基线比较，即有明显降低(P=0.000)，PANSS总减分率为1 3.2%。治疗第6周末，PANSS总分减分率达68.1%，治疗有效率76.5%，发生不良反应61次，主要不良反应：静坐不能、震颤、肌张力障碍等，且程度轻微。每粒国产利培酮较进口利培酮少1.45元。结论：国产利培酮治疗精神分裂症有效安全、经济。

    【关键词】国产利培酮；精神分裂症；有效性；安全性；经济性

    Risperidone in the treatment of schizophrenia made of the efficacy, safety and economic studies

    ZHANGHua

    【Abstract】 Objective: To explore the domestic risperidone in the treatment of schizophrenia, safety and economy. Methods: 120 cases of schizophrenia patient or out-patient use of risperidone in the treatment of Chinese-made 6 weeks before and after treatment were carried out in positive and negative symptom scale (PANSS) Test. Results: The treatment of the first weekend, PANSS total scores and sub-sub-scales compared with the baseline, that is significantly lower (P = 0.000), PANSS total reduction rate of 1 to 3.2%. Treatment No. 6 over the weekend, PANSS total score reduction rate of 68.1 percent, 76.5 percent efficiency of treatment, 61 adverse reactions occurred, the main side effects: akathisia, tremor, dystonia, etc.And minor. Each Chinese-made imports Risperidone Risperidone less than 1.45 yuan. Conclusion: Risperidone treatment of schizophrenia made effective security, economic. ......