气相色谱法测定磺胺二甲嘧啶有机溶剂残留量
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【摘要】目的:建立磺胺二甲嘧啶合成中所用丙酮有机溶剂残留量测定方法。方法:采用毛细管气相色谱法,溶液直接进样,氢火焰离子化检测器(FID),以二甲基亚砜为溶剂,色谱柱为Supelcowax-10(30m×0.32mm×0.5μm),进样口温度160℃,检测器温度250℃,柱温 120℃,载气为氮气。结果:在该色谱条件下丙酮与二甲基亚砜能达到完全分离,测得丙酮线性试验所得回收方程相关系数在0.9968%,加样回收率分别为98.5%-102.8% , RSD<2.0%。结论:该法可以作为磺胺二甲嘧啶原料药中有机溶剂残留量的检测。
【关键词】磺胺二甲嘧啶;气相色谱法;残留有机溶剂
【Abstract】Objective: To develop a GC method for determination of acetone in sulfadimidine.Method: Using Supelcowax-10 capillary column (30m×0.32mm×0.5μm),FID detector, the samples were dissolved in dimethyl sulphoxide, and sampling directly. The initial temperature was 120℃ ,the injection port and detector temperature were 160℃ and 250℃ respectively, using Nitrogen gas as carrier gas. Result: In these chromatographic conditions acetone and dimethyl sulphoxide were completely separated ......
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