阿奇霉素联合头孢他啶治疗社区获得性肺炎的临床观察(1)
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【摘要】目的:探讨阿奇霉素联合头孢他啶治疗社区获得性肺炎的临床疗效和安全性。方法:将80例患者随机分成两组观察组和对照组各40例,观察组应用阿奇霉素联合头孢他啶治疗,对照组应用红霉素联合头孢他啶,观察并比较两组治疗前后症状情况和并发症。疗效评价依据症状、体征、实验室检查恢复以及致病菌的清除;不良反应根据治疗前后肝、肾功能改变及恶心、呕吐等消化道反应。结果:观察组治疗有效率、细菌清除率分别为95.00%、93.75%,高于对照组的75.00%、70.00%,差异存在统计学意义(P<0.05);观察组不良反应20.00%,对照组为17.50%,不良反应发生率比较无统计学意义(P>0.05)。结论:阿奇霉素联合头孢他啶治疗社区获得性肺炎临床疗效好,安全性性,值得临床推广应用。
【关键词】阿奇霉素;头孢他啶;红霉素;社区获得性肺炎
doi:10.3969/j.issn.1006-1959.2010.08.006文章编号:1006-1959(2010)-08-1981-02
The observation on clinical effect of azithromycin and ceftazidime treating community acquired pneumoniaFAN Yi-Shi
Department of Respiratory Medicine,The Fourth People's Hospital Of Ziyang city,SiChuan,641300
【Abstract】Objective:To explore the clinical effect and safety of azithromycin and ceftazidime treating community acquired pneumonia.Methods:80 patients with community acquired pneumonia were randomly divided into the intervention group(40 cases) and control group(40 cases).The intervention group were treated with azithromycin and ceftazidime,the control group were treated with erythromycin and ceftazidime;Symptoms and drug sensitiveness of two groups were observed respectively before and after treatment.The efficacies were evaluated according the therapeutic indices,including symptom,sign,recovery of laboratory examination and clearance rate of pathogenic bacteria,and the adverse reaction indices,including the shift of liver,renal functions pre/post treatment,the occurrence of alimentary tract reactions such as nausea,vomiting.Results:The effective rate、bacterial clearing rate in the intervention group were 95.00%、93.75% respectively,were high 75.00%、70.00% in the control group,it was significantly (P<0.05);The occurrence of the adverse reaction rate in the intervention group was 20.00%,and 17.50% in the control group,it was no significantly(P>0.05).Conclusion:The azithromycin and ceftazidime treating community acquired pneumonia is more effective and safely,and hence is worthy of being recommended in clinical practice.
【Key words】Azithromycin;Ceftazidime;Erythromycin;Community acquired pneumonia
社区获得性肺炎(community acquired pneumonia,CAP)是指在医院外罹患的感染性肺实质(含肺泡壁即广义上的肺间质)炎症,包括具有明确潜伏期的病原体感染而入院后平均潜伏期内发病的肺炎[1] ......
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