摘要：基于空间约束的蛋白质结构预测方法是一种以已知结构为模板预测蛋白质结构的方法。其中，它提取了模板结构中的同源约束，结合力场中的立体化学约束，作为优化初始结构的条件，从而对初始结构进行调整，最终得到模型。本文主要综述了基于空间约束的蛋白质结构预测方法的原理，所涉及的空间约束，以及应用与软件。

    关键词：蛋白质结构预测；空间约束；同源模建

    Abstract：Comparative modeling based on spare restraints is one of protein structure prediction methods which predict the three-dimensional structure of a given protein sequence based primarily on its alignment to one or more protein of known structure. This method uses homology-derived restraints from template protein and stereochemical restraints from force field as constraints to optimize initial structure ......