儿泻停颗粒佐治婴幼儿抗生素相关性腹泻临床分析(1)
摘要：目的 观察儿泻停颗粒佐治婴幼儿抗生素相关性腹泻的临床疗效。方法 采用随机、开放、平行对照的临床试验方法，连续纳入180例2013年1月～2014年12月在我院消化专科考虑抗生素相关性腹泻病的患儿，随机分成A酪酸梭菌组、B儿泻停组、C酪酸梭菌+儿泻停组，三组均口服蒙脱石散、ORS治疗，及其他对症处理，观察并比较治疗后第3 d及第5 d的疗效及药物相关不良反应。结果 169例完成了观察，其中A组56例，B组55例，C组58例，三组患儿在年龄、性别构成、体重、病程、病情轻重程度等方面均无统计学差异(P>0.05)，三组第3 d和第5 d的治愈率分别为A组16.07%、28.57%，B组14.55%、25.45%，C组25.86%、43.10%；总有效率分别为A组55.36%、67.86%，B组49.09%、67.27%，C组68.97%、81.03%。运用SAS9.3软件，以A组为对照组进行单因素与多因素logistic回归分析，经校正其他变量后，C组第3d OR治愈(95%CI)=3.796(1.163，12.386)，OR有效(95%CI)=2.926(1.212，7.061)，第5d OR治愈(95%CI)=2.453(1.013，5.942)，OR有效(95%CI)=3.163(1.153，8.679)，提示C組疗效优于A组，B组与A组疗效差异无统计学意义，观察期间未见明显药物相关不良反应。结论 儿泻停颗粒治疗婴幼儿抗生素相关性腹泻疗效与酪酸梭菌相似，儿泻停颗粒联合酪酸梭菌治疗的效果优于酪酸梭菌治疗组，可使婴幼儿抗生素相关性腹泻治愈的概率增加，安全性好。
, 百拇医药
关键词：儿泻停颗粒；酪酸梭菌；抗生素相关性腹泻
Abstract：Objective To observe Erxieting Granule treatment infants and young children the clinical curative effect of antibiotic associated diarrhea .Methods Adopts randomized， open， parallel controlled clinical trial method， continuous in 180 cases between January 2013 and December 2013 in our hospital during digestion college consider antibiotic associated diarrhea disease in children， randomly divided into A set of butyric acid bacteria， son xie ting group B， group C + son xie ting butyric acid bacteria， three groups all oral montmorillonite powder， ORS treatment， and other symptomatic treatment， observe and compare the curative effect of 3 days and 5 days after treatment， and drug related adverse reaction Results 169 patients completed the observation， including 56 cases of group A， B group of 55 cases， 58 cases of group C， three groups of children in age， gender， weight， duration， and degree of illness weight had no statistical difference (P >0.05)， the cure rate of three groups of 3 and 5 days respectively 16.07%， 28.57% of group A， group B were 14.55%， 25.45%， 25.86%， 43.10%； group C Total effective rate in group A were respectively 55.36% and 67.86%， B group were 49.09%， 67.27%， 68.97%， C81.03 group C %， using SAS9.3 software， with A group to the control group carries on the single factor and multiple factors logistic regression analysis， after correction for other variables， ORcure 3 days to group C (95% CI) = 3.796 (1.163， 1.163)， OR effective(95% CI) = 2.926 (1.212， 1.212)， 5 days OR cure (95% CI) = 2.453 (1.013， 1.013)， OR effective (95% CI) = 3.163 (1.153， 1.153)， prompt curative effect is better than that of group A， group C and group B there was no statistically significant difference effect of group A， did not see obvious drug related adverse reactions during observation. Conclusion Erxieting Granule infant antibiotic associated diarrhea curative effect similar to butyric acid bacteria， Erxieting Granule with clostridium butyric acid therapy effect is better than that of the treatment group， butyric acid bacteria can increase the probability of an infant antibiotic associated diarrhea cure， good safety., 百拇医药(周诗琼 梅红 彭罕鸣 王宝香)
, 百拇医药
关键词：儿泻停颗粒；酪酸梭菌；抗生素相关性腹泻
Abstract：Objective To observe Erxieting Granule treatment infants and young children the clinical curative effect of antibiotic associated diarrhea .Methods Adopts randomized， open， parallel controlled clinical trial method， continuous in 180 cases between January 2013 and December 2013 in our hospital during digestion college consider antibiotic associated diarrhea disease in children， randomly divided into A set of butyric acid bacteria， son xie ting group B， group C + son xie ting butyric acid bacteria， three groups all oral montmorillonite powder， ORS treatment， and other symptomatic treatment， observe and compare the curative effect of 3 days and 5 days after treatment， and drug related adverse reaction Results 169 patients completed the observation， including 56 cases of group A， B group of 55 cases， 58 cases of group C， three groups of children in age， gender， weight， duration， and degree of illness weight had no statistical difference (P >0.05)， the cure rate of three groups of 3 and 5 days respectively 16.07%， 28.57% of group A， group B were 14.55%， 25.45%， 25.86%， 43.10%； group C Total effective rate in group A were respectively 55.36% and 67.86%， B group were 49.09%， 67.27%， 68.97%， C81.03 group C %， using SAS9.3 software， with A group to the control group carries on the single factor and multiple factors logistic regression analysis， after correction for other variables， ORcure 3 days to group C (95% CI) = 3.796 (1.163， 1.163)， OR effective(95% CI) = 2.926 (1.212， 1.212)， 5 days OR cure (95% CI) = 2.453 (1.013， 1.013)， OR effective (95% CI) = 3.163 (1.153， 1.153)， prompt curative effect is better than that of group A， group C and group B there was no statistically significant difference effect of group A， did not see obvious drug related adverse reactions during observation. Conclusion Erxieting Granule infant antibiotic associated diarrhea curative effect similar to butyric acid bacteria， Erxieting Granule with clostridium butyric acid therapy effect is better than that of the treatment group， butyric acid bacteria can increase the probability of an infant antibiotic associated diarrhea cure， good safety., 百拇医药(周诗琼 梅红 彭罕鸣 王宝香)
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