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探讨不同蓝光照射方法治疗新生儿黄疸的疗效及不良反应(1)
http://www.100md.com 2017年1月15日 《医学信息》 2017年第2期
     摘要:目的 研究和探索不同蓝光照射方法治疗新生儿黄疸的临床疗效和不良反应。方法 选择我院2014年11月~2015年11月接收的新生儿黄疸患儿130例,均为血清非结合胆红素增高病例,随机平均分组使用持续蓝光照射和间歇蓝光照射治疗患儿,对比和分析两组患儿临床治疗效果和不良反应发生率等。结果 观察组患儿显效29例,临床治疗有效率为89.23%;对照组患儿显效26例,临床治疗有效率为87.69%。观察组患儿皮疹7例,发热4例,呕吐腹泻11例,临床不良反应发生率为33.85%;对照组患儿皮疹10例,发热6例,呕吐腹泻18例,临床不良反应发生率为52.31%。且P<0.05差异具有统计学意义,对比具有临床参考价值。结论 间歇蓝光和持续蓝光照射治疗均能够明显地改善新生儿黄疸的临床症状,在临床治疗效果方面没有明显差异,但是间歇蓝光照射治疗能够明显地降低患儿临床不良反应的发生率,具有推广价值。

    关键词:间歇蓝光照射;持续蓝光照射;新生儿黄疸;不良反应

    Efficacy and Adverse Reactions of Different Blue Light Irradiation in the Treatment of Neonatal Jaundice
, http://www.100md.com
    FANG Yan

    (Department of Pediatrics,Shizhong District Maternal and Child Health Care Hospital,Leshan 614000,Sichuan,China)

    Abstract:Objective To study and explore the clinical efficacy and adverse reactions of different blue light irradiation in the treatment of neonatal jaundice. Methods 130 cases of neonatal jaundice in our hospital from November 2014 to November 2015 were received, serum unconjugated bilirubin increased were randomly divided into two equal groups using continuous blue light and intermittent blue light irradiation in the treatment of children, comparison and analysis of two groups of clinical curative effect and adverse reaction rate. Results In the observation group, 29 cases were markedly effective, the effective rate was 89.23%; the control group was 26 cases, the effective rate was 87.69%. The observation group with 7 cases in 4 cases of skin rash, fever, vomiting and diarrhea in 11 cases, the clinical adverse reaction rate was 33.85%; 10 cases of the control group with 6 cases of fever, rash, vomiting and diarrhea in 18 cases, the clinical adverse reaction rate was 52.31%. And P<0.05 difference has statistical significance, compared with the clinical reference value. Conclusion The clinical symptoms of intermittent and continuous blue light blue light treatment can significantly improve the neonatal jaundice, there is no significant difference in clinical treatment, but the intermittent blue light treatment can significantly reduce the incidence of adverse reaction cases, has the value of popularization.
, 百拇医药
    Key words:Intermittent blue light irradiation;Continuous blue light irradiation;Neonatal jaundice;Adverse reactions

    黃疸是由于各种原因造成体内胆红素生成过多,导致血液内血胆红素浓度过高无法正常排出体外,造成肝脏负荷过重,引起患者粘膜、眼睛巩膜和皮肤出现发黄现象的疾病,是新生儿常见的临床病症,极易造成听力和智力受损,甚至死亡[1]。通常,出世未满28 d的新生儿极易出现黄疸症状[2],通常足月儿生理性黄疸在生后5~7 d左右逐渐消退,早产儿在生后7~9 d消退,病理性黄疸则可严重影响中枢神经系统,造成永久不可挽回的伤害。 一般早产儿出现黄疸的几率高达80%左右,随着年龄增长,婴儿抵抗力免疫系统的生成,黄疸的发生率逐渐降低。蓝光疗法是指运用波长在425~475nm的蓝光,对患者的皮肤裸露部分进行照射,血中非结合胆红素转变成为的水溶性异构体,包括4Z、15E异构体和结构异构体,从而达到细胞结构的异变效果,上述异构体可不经过肝脏处理直接经胆汁和尿液排除。本文主要研究间歇和持续蓝光照射治疗的临床疗效和应用价值,详细报告如下。, http://www.100md.com(方妍)
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