血清胱抑素C、尿酸与缺血性脑血管病颈动脉粥样硬化的关系(1)
摘要：目的 探討血清胱抑素C、尿酸与缺血性脑血管病患者颈动脉粥样硬化的关系。方法 选择缺血性脑血管病患者250例，应用彩色多普勒超声检查患者颈动脉内-中膜厚度(IMT)，综合评估患者颈动脉粥样硬化程度及斑块性质。选择同期250名年龄和性别相匹配的健康体检者作为对照组，观察两组之间胱抑素C、尿酸的差异。运用逻辑回归分析方法分析血清胱抑素C、尿酸对缺血性脑血管病患者颈动脉粥样硬化的作用。结果 ①病例组血清胱抑素C值[1.00(0.21)μmol/L]显著高于对照组[0.92(0.17)μmol/L]，病例组尿酸值[300(85.25)μmol/L]显著高于对照组[286(94.25)μmol/L]，差异均有统计学意义(均P<0.05)；②缺血性脑血管病患者颈动脉IMT增厚组和斑块形成组血清胱抑素C浓度显著高于颈动脉IMT正常组，斑块形成组尿酸水平显著高于颈动脉IMT正常组，差异均有统计学意义(P<0.05)，其余组间比较差异无统计学意义(P>0.05)。③多元逻辑回归分析显示，胱抑素C水平升高是颈动脉粥样斑块形成的独立危险因素(OR=1.052，95%CI：1.029-1.075)。结论 ①血清胱抑素C、尿酸水平升高是发生缺血性脑血管病的重要危险因素；②血清胱抑素C升高与缺血性脑血管病患者颈动脉粥样硬化的形成及发展密切相关，检测血清胱抑素C水平可以反映其颈动脉粥样硬化程度。
, 百拇医药
关键词：缺血性脑血管病；颈动脉粥样硬化；血清胱抑素C；尿酸
The Relationship between Serum Cystatin C， Uric Acid and Carotid Atherosclerosis in Ischemic Cerebrovascular Disease
FEI Lin，WANG Yong-hong
(Department of Internal Medicine-Neurology，First Affiliated Hospital of Chongqing Medical University，Chongqing 400016，China)
Abstract：Objective To investigate the relationship betweenserumcystatin C (Cys-C) ，uric acid (UA) level andcarotid atheroscleroticin patientswith ischemic cerebrovascular disease(ICVD). Methods A total of 250 patients with first-ever ischemic stroke.Color Doppler ultrasound of carotid artery wasused to detect the carotid artery intima-mediathickness (IMT).The degree of CAS in patients was assessed comprehensively.selecting 250 age and sex-matched healthy controls as control group.The Cys-C，UA concentrations indexes were measuredby an enzymatic method and carefully analyzed.Therelationship betweenthe serum Cys-C，UA level and the carotid atherosclerotic plaques were analyzed. Results ①The levels of Cys-C，UA in patients with ischemic cerebrovascular disease was higher than thatof the controlsubjects(P<0.05).②Wefound that the serum Cys-Clevelsinboth IMT thickening and the plaque formation groupswere significantly higher than the normal IMT group(P<0.05).And UA levels of the plaque formation group were significantly higher than the normalIMT group(P<0.05).③Multivariate logistic regression analysisshowed that the increasedCys-C level was an independent risk factor for carotidatherosclerotic plaque formation(OR =1.052，95%CI： 1.029-1.075).Conclusion Cystatin-C， Uric acid are independentrisk factors forischemic cerebrovascular disease.Cys-C is an independentrisk factor for carotid atherosclerotic plaque formationin patients with ischemic cerebrovascular disease.
Key words：Ischemic cerebrovascular disease；Atherosclerosis； Cystatin-C；Uric acid, 百拇医药(费琳 王永红)
, 百拇医药
关键词：缺血性脑血管病；颈动脉粥样硬化；血清胱抑素C；尿酸
The Relationship between Serum Cystatin C， Uric Acid and Carotid Atherosclerosis in Ischemic Cerebrovascular Disease
FEI Lin，WANG Yong-hong
(Department of Internal Medicine-Neurology，First Affiliated Hospital of Chongqing Medical University，Chongqing 400016，China)
Abstract：Objective To investigate the relationship betweenserumcystatin C (Cys-C) ，uric acid (UA) level andcarotid atheroscleroticin patientswith ischemic cerebrovascular disease(ICVD). Methods A total of 250 patients with first-ever ischemic stroke.Color Doppler ultrasound of carotid artery wasused to detect the carotid artery intima-mediathickness (IMT).The degree of CAS in patients was assessed comprehensively.selecting 250 age and sex-matched healthy controls as control group.The Cys-C，UA concentrations indexes were measuredby an enzymatic method and carefully analyzed.Therelationship betweenthe serum Cys-C，UA level and the carotid atherosclerotic plaques were analyzed. Results ①The levels of Cys-C，UA in patients with ischemic cerebrovascular disease was higher than thatof the controlsubjects(P<0.05).②Wefound that the serum Cys-Clevelsinboth IMT thickening and the plaque formation groupswere significantly higher than the normal IMT group(P<0.05).And UA levels of the plaque formation group were significantly higher than the normalIMT group(P<0.05).③Multivariate logistic regression analysisshowed that the increasedCys-C level was an independent risk factor for carotidatherosclerotic plaque formation(OR =1.052，95%CI： 1.029-1.075).Conclusion Cystatin-C， Uric acid are independentrisk factors forischemic cerebrovascular disease.Cys-C is an independentrisk factor for carotid atherosclerotic plaque formationin patients with ischemic cerebrovascular disease.
Key words：Ischemic cerebrovascular disease；Atherosclerosis； Cystatin-C；Uric acid, 百拇医药(费琳 王永红)
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