阿奇霉素联合替硝唑治疗小儿幽门螺杆菌性胃炎的临床疗效分析(1)
摘要：目的 分析阿奇霉素联合替硝唑治疗小儿幽门螺杆菌(Hp)性胃炎的临床疗效。方法 116例小儿Hp性胃炎患儿，随机分为治疗组和对照组，各58例。对照组患儿使用阿莫西林联合甲硝唑治疗，治疗组患儿使用阿奇霉素联合替硝唑治疗，比较两组治疗效果。结果 治疗组患儿治疗显效37例，有效15例，无效6例，总有效率为89.66%；对照组患儿治疗显效24例，有效12例，无效22例，总有效率为62.07%。治疗组患儿总有效率明显高于对照组(P<0.05)；治疗组患儿发生并发症2例，并发症发生率为3.45%，对照组患儿发生并发症4例，并发症发生率为6.90%，比较差异无统计学意义(P>0.05)。结论 对小儿Hp相关性胃炎患儿实施阿奇霉素联合替硝唑的治疗，能够在保证安全性的前提下明显提升治疗效果，有着极高应用价值，值得推广使用。
关键词：阿奇霉素；替硝唑；小儿幽门螺杆菌相关性胃炎；临床疗效
Abstract： Objective Analysis of Azithromycin combined with tinidazole in treatment of children with Helicobacter pylori(Hp)clinical curative effect of gastritis.Methods 116 cases of Hp gastritis were randomly divided into treatment group and control group，each of 58 cases.The control group used amoxicillin combined with metronidazole treatment，treatment group used Azithromycin combined with tinidazole in treatment，treatment effects were compared between the two groups.Results The treatment group 37 cases were markedly effective，15 cases effective，6 cases ineffective，the total effective rate was 89.66%；the control group 24 cases were markedly effective，12 cases effective，22 cases ineffective，the total efficiency of the 62.07%. treatment group in the total efficiency was significantly higher than the control group(P<0.05)；the treatment group in complications occurred in 2 cases， the complication rate was 3.45%， the control group were 4 cases of complications，the complication rate was 6.90%，the difference was not statistically significant(P>0.05).Conclusion The implementation of the arch mildew on children with Hp associated gastritis in children the treatment combined with tinidazole，can ensure the safety of the premise significantly improve the therapeutic effect，has a high application value， worthy of promotion.
, 百拇医药
Key words：Azithromycin；Tinidazole；Children with Helicobacter pylori associated gastritis；Clinical curative effect
幽門螺杆菌(Helicobacter pylori，Hp)感染是引起消化性溃疡，特别是十二指肠溃疡的主要致病原因，根除幽门螺杆菌(以下简称为Hp)后可以使溃疡愈合，缩短溃疡的病程，并使溃疡的复发率明显降低。国内外对根除Hp采用多种方案，并广泛应用于临床，但各方案有效性、依从性、副作用大小不一。小儿胃炎属于一种发病率较高的疾病，其致病因素主要是幽门螺杆菌(以下简称为Hp)，为一种常见的慢性活动性胃炎，需要及时地对其进行治疗，否则患者会出现消化性溃疡等并发症，可对其生命安全与健康构成一定威胁。在以往治疗小儿胃炎时，替硝唑属于基础性的治疗药物，可以在一定程度上缓解患者的病情，但是单一用药的效果较差，因此，往往需要与阿莫西林或者阿奇霉素联合使用[1]。本组选取116例小儿胃炎患者进行分组研究，旨在观察阿奇霉素与替硝唑的联合疗法的应用价值，获得了较为理想的研究结果，现作如下汇报。
1 资料与方法
1.1一般资料 研究对象为本院2015年12月～2016年9月收治的小儿Hp相关性胃炎患儿116例。其中男80例，女26例，年龄3～12岁，平均年龄(6.12±3.33)岁。所有患儿均确诊为小儿Hp相关性胃炎。将其依自愿原则随机分成对照组和治疗组，每组58例。对照组中男42例，女16例， 年龄3～10岁，平均年龄(5.81± 3.42)岁；治疗组中男48例，女10例，年龄3～11岁，平均年龄(6.5±2.7)岁。两组患儿在性别、平均年龄等方面均不存在统计学差异(P>0.05)，具有可比性。, 百拇医药(曾绍琦)
关键词：阿奇霉素；替硝唑；小儿幽门螺杆菌相关性胃炎；临床疗效
Abstract： Objective Analysis of Azithromycin combined with tinidazole in treatment of children with Helicobacter pylori(Hp)clinical curative effect of gastritis.Methods 116 cases of Hp gastritis were randomly divided into treatment group and control group，each of 58 cases.The control group used amoxicillin combined with metronidazole treatment，treatment group used Azithromycin combined with tinidazole in treatment，treatment effects were compared between the two groups.Results The treatment group 37 cases were markedly effective，15 cases effective，6 cases ineffective，the total effective rate was 89.66%；the control group 24 cases were markedly effective，12 cases effective，22 cases ineffective，the total efficiency of the 62.07%. treatment group in the total efficiency was significantly higher than the control group(P<0.05)；the treatment group in complications occurred in 2 cases， the complication rate was 3.45%， the control group were 4 cases of complications，the complication rate was 6.90%，the difference was not statistically significant(P>0.05).Conclusion The implementation of the arch mildew on children with Hp associated gastritis in children the treatment combined with tinidazole，can ensure the safety of the premise significantly improve the therapeutic effect，has a high application value， worthy of promotion.
, 百拇医药
Key words：Azithromycin；Tinidazole；Children with Helicobacter pylori associated gastritis；Clinical curative effect
幽門螺杆菌(Helicobacter pylori，Hp)感染是引起消化性溃疡，特别是十二指肠溃疡的主要致病原因，根除幽门螺杆菌(以下简称为Hp)后可以使溃疡愈合，缩短溃疡的病程，并使溃疡的复发率明显降低。国内外对根除Hp采用多种方案，并广泛应用于临床，但各方案有效性、依从性、副作用大小不一。小儿胃炎属于一种发病率较高的疾病，其致病因素主要是幽门螺杆菌(以下简称为Hp)，为一种常见的慢性活动性胃炎，需要及时地对其进行治疗，否则患者会出现消化性溃疡等并发症，可对其生命安全与健康构成一定威胁。在以往治疗小儿胃炎时，替硝唑属于基础性的治疗药物，可以在一定程度上缓解患者的病情，但是单一用药的效果较差，因此，往往需要与阿莫西林或者阿奇霉素联合使用[1]。本组选取116例小儿胃炎患者进行分组研究，旨在观察阿奇霉素与替硝唑的联合疗法的应用价值，获得了较为理想的研究结果，现作如下汇报。
1 资料与方法
1.1一般资料 研究对象为本院2015年12月～2016年9月收治的小儿Hp相关性胃炎患儿116例。其中男80例，女26例，年龄3～12岁，平均年龄(6.12±3.33)岁。所有患儿均确诊为小儿Hp相关性胃炎。将其依自愿原则随机分成对照组和治疗组，每组58例。对照组中男42例，女16例， 年龄3～10岁，平均年龄(5.81± 3.42)岁；治疗组中男48例，女10例，年龄3～11岁，平均年龄(6.5±2.7)岁。两组患儿在性别、平均年龄等方面均不存在统计学差异(P>0.05)，具有可比性。, 百拇医药(曾绍琦)
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