磁共振成像和血清铁蛋白评估铁过载的对比研究(1)
摘要：目的 本研究选取出现铁蛋白升高的血液病患者，比较肝脏T2*与血清铁蛋白评估血液病患者铁过载的特征，以确定更为合适的铁过载评估方法。方法 选取2015年11月～2017年1月就诊于安徽医科大学的血液病患者，测定患者肝脏T2*值及血清铁蛋白浓度，并对收集到的数据进行分析处理。结果 14例患者中男5例，女9例，肝T2*中位数为4.24(1.52～14.32)ms，有12例患者(85.70%)肝脏存在铁过载。14例患者的肝T2*与血清铁蛋白显著负相关(r=-0.547，P=0.043)，肝T2*与输血量之间呈线性相关(r2=0.67，P=0.01)，而血清铁蛋白与输血量没有相关性(r2=0.299，P=0.051)。无祛铁治疗的10例患者肝T2*与血清铁蛋白显著相关(r=-0.866，P=0.001)，肝T2*、血清铁蛋白与输血量呈线性相关(r2=0.6，P=0.009；r2=0.63，P=0.006)。结论 肝脏T2*与血清铁蛋白之间存在显著的负相关性，肝脏T2*值更能准确的描述铁过载情况，对轻度铁过载更敏感，可信度及重复性更佳。
, http://www.100md.com
关键词：磁共振成象；肝脏T2*；血清铁蛋白；铁过载
中图分类号：R445.2 文献标识码：A 文章編号：1006-1959(2017)00-0061-03 Comparative Study of Magnetic Resonance Imaging and Serum Ferritin in Assessing Iron Overload
LI Chen-peng，ZHAI Zhi-min，TAO Qian-shan
(Department of Hematology，the Second Affiliated Hospital of Medical University Of Anhui，Hefei 230601，Anhui，China)
Abstract：Objective In this study，patients with elevated serum levels of ferritin were selected to compare the characteristics of iron overload in the liver with T2* and serum ferritin to determine the more appropriate iron overload assessment method.Methods From November 2015～January 2017 in medical university of Anhui hospital blood disease patients were measured T2* value of liver and serum ferritin concentrations，and the collected data were analyzed.Results In 14 cases，male 5 cases，female 9 cases，liver T2* was 4.24(1.52～14.32) ms，12 patients(85.7%)liver iron overload.14 patients with liver T2* and serum ferritin were significantly negative correlation(r=-0.547，P=0.043)，there was a linear correlation between the liver T2* and blood transfusion(r2=0.67，P=0.01)，liver T2* and serum ferritin and blood transfusion had no correlation(r2=0.299，P=0.051).No significant related to iron chelation therapy in 10 patients liver T2* and serum ferritin(r=-0.866，P=0.001)，liver T2*，a linear correlation between serum ferritin and blood transfusion volume(r2=0.6，P=0.009；r2=0.63，P=0.006).Conclusion There was a significantly negative correlation between the conclusion of the liver T2* and serum ferritin，liver T2* could more accurately describe the iron overload situation，more sensitive to mild iron overload，reliability and better repeatability.
, 百拇医药
Key words：Magnetic resonance imaging；Liver T2*；Serum ferritin；Iron overload
骨髓增生异常综合征、再生障碍性贫血等血液系统疾病，其患者往往因骨髓造血功能异常，而需要长期输血治疗。尽管这些治疗有着救命的好处，但输血可以引起进一步的并发症，特别是铁过载。铁过载危害巨大，产生氧自由基攻击靶器官的细胞膜、DNA，最终引起靶器官功能障碍，临床上表现为心力衰竭、肝硬化等，严重影响患者的生活质量和生命安全[1]。对于铁过载的患者来说，需要不断检测体内铁负荷并及时行祛铁治疗。磁共振成像是一种非侵袭性技术，已经被认为是一个可靠的方法检测不同器官如肝与心铁沉积情况。有研究证实了使用MRI测量肝铁含量和肝脏活组织检查检测量肝铁含量有良好的相关性[2]。, 百拇医药(李陈芃 翟志敏 陶千山)
, http://www.100md.com
关键词：磁共振成象；肝脏T2*；血清铁蛋白；铁过载
中图分类号：R445.2 文献标识码：A 文章編号：1006-1959(2017)00-0061-03 Comparative Study of Magnetic Resonance Imaging and Serum Ferritin in Assessing Iron Overload
LI Chen-peng，ZHAI Zhi-min，TAO Qian-shan
(Department of Hematology，the Second Affiliated Hospital of Medical University Of Anhui，Hefei 230601，Anhui，China)
Abstract：Objective In this study，patients with elevated serum levels of ferritin were selected to compare the characteristics of iron overload in the liver with T2* and serum ferritin to determine the more appropriate iron overload assessment method.Methods From November 2015～January 2017 in medical university of Anhui hospital blood disease patients were measured T2* value of liver and serum ferritin concentrations，and the collected data were analyzed.Results In 14 cases，male 5 cases，female 9 cases，liver T2* was 4.24(1.52～14.32) ms，12 patients(85.7%)liver iron overload.14 patients with liver T2* and serum ferritin were significantly negative correlation(r=-0.547，P=0.043)，there was a linear correlation between the liver T2* and blood transfusion(r2=0.67，P=0.01)，liver T2* and serum ferritin and blood transfusion had no correlation(r2=0.299，P=0.051).No significant related to iron chelation therapy in 10 patients liver T2* and serum ferritin(r=-0.866，P=0.001)，liver T2*，a linear correlation between serum ferritin and blood transfusion volume(r2=0.6，P=0.009；r2=0.63，P=0.006).Conclusion There was a significantly negative correlation between the conclusion of the liver T2* and serum ferritin，liver T2* could more accurately describe the iron overload situation，more sensitive to mild iron overload，reliability and better repeatability.
, 百拇医药
Key words：Magnetic resonance imaging；Liver T2*；Serum ferritin；Iron overload
骨髓增生异常综合征、再生障碍性贫血等血液系统疾病，其患者往往因骨髓造血功能异常，而需要长期输血治疗。尽管这些治疗有着救命的好处，但输血可以引起进一步的并发症，特别是铁过载。铁过载危害巨大，产生氧自由基攻击靶器官的细胞膜、DNA，最终引起靶器官功能障碍，临床上表现为心力衰竭、肝硬化等，严重影响患者的生活质量和生命安全[1]。对于铁过载的患者来说，需要不断检测体内铁负荷并及时行祛铁治疗。磁共振成像是一种非侵袭性技术，已经被认为是一个可靠的方法检测不同器官如肝与心铁沉积情况。有研究证实了使用MRI测量肝铁含量和肝脏活组织检查检测量肝铁含量有良好的相关性[2]。, 百拇医药(李陈芃 翟志敏 陶千山)