出生体重对新生儿促甲状腺素水平及先天性甲状腺功能低下症发病率的影响(1)
摘要：目的 探讨出生体重对新生儿促甲状腺素(TSH)水平的影响以及与先天性甲状腺功能低下症(CH)发病率的关系。方法 利用荧光酶免疫方法对226390例新生儿进行足底血片TSH筛查，TSH≥9 mU/L者为筛查阳性，若复查TSH仍≥9 mU/L则召回测定TSH、FT3、FT4作出诊断。按照不同出生体重进行分组，分析不同出生体重新生儿TSH水平及CH的发病率。结果 不同出生体重的新生儿TSH初筛阳性率总体差异有统计学意义(P<0.05)，CH发病率差异有统计学意义(P<0.05)。结论 新生儿TSH水平、 CH的发病与新生儿的出生体重有关。低出生体重儿TSH初筛阳性率较低。低出生体重儿、巨大兒的发病率较高。为了防止低出生体重儿TSH较低所带来的筛查假阴性，在新生儿筛查阶段对低出生体重宜推迟采集测定足跟血TSH。注意孕期保健防止巨大儿、低出生体重儿，对降低先天性甲状腺功能异常的发生有重大意义。
关键词：新生儿筛查；先天性甲状腺功能低下；出生体重；促甲状腺素；发病率
, 百拇医药 中图分类号：R722.1 文献标识码：A 文章编号：1006-1959(2017)21-0052-02
Effects of Birth Weight on Thyroid Stimulating Hormone Levels and Incidence of Congenital Hypothyroidism in Neonates
CHEN Jin-guo，ZHONG Yu-hang，CAI Xiao-juan，YE Li-xin，XIE Cai-lian
(Dongguan City Maternal and Child Health Care Neonatal Disease Screening Center，Dongguan 523000，Guangdong，China)
Abstract：Objective To investigate the birth weight of neonatal thyroid stimulating hormone(TSH)level and with congenital hypothyroidism(CH) incidence.Methods Using fluorescence enzyme immunoassay method for plantar blood TSH in 226390 cases of neonatal screening，TSH≥9 mU/L for screening positive，if TSH was still ≥9 mU/L recall is the determination of TSH，FT3，FT4.The diagnosis were grouped according to the different birth weight，TSH level and CH analysis of different birth weight of newborns.Results The incidence of different birth weight neonatal TSH screening positive rate difference was statistically significant(P<0.05)，there were statistically significant differences in the incidence rate of CH(P<0.05). Conclusion Neonatal TSH levels，CH incidence and neonatal birth weight.Low birth weight TSH screening positive rate is low.Low birth weight children，the incidence of huge children higher.In order to prevent the low birth weight of children with low TSH caused by screening false negative，in the neonatal screening stage of low birth weight should be delayed acquisition of heel blood TSH.Attention to health care during pregnancy to prevent huge children，low birth weight children，to reduce the occurrence of congenital thyroid dysfunction is of great significance.
, 百拇医药
Key words：Neonatal screening；Congenital hypothyroidism；Birth weight；Thyrotropin；Incidence
先天性甲状腺功能低下(CH)是一种由于先天性原因使甲状腺激素合成障碍、甲状腺素缺乏而导致患儿生长迟缓、智力发育落后的一种常见的内分泌疾病。该病在新生儿期往往因为症状轻微或者缺乏典型的甲状腺功能低下的症状和体征容易误诊。通过新生儿疾病筛查有利于本病早期发现，早期治疗。为了解比较不同出生体重新生儿的促甲状腺素(TSH)水平和CH发病率，本文对226390例新生儿筛查血片TSH检测结果及临床确诊结果进行统计分析，报告如下。
1 资料与方法
1.1一般资料
东莞市出生的有出生体重信息的活产新生儿共226390例。, http://www.100md.com(陈锦国 钟玉杭 蔡小娟 叶立新 谢彩连)
关键词：新生儿筛查；先天性甲状腺功能低下；出生体重；促甲状腺素；发病率
, 百拇医药 中图分类号：R722.1 文献标识码：A 文章编号：1006-1959(2017)21-0052-02
Effects of Birth Weight on Thyroid Stimulating Hormone Levels and Incidence of Congenital Hypothyroidism in Neonates
CHEN Jin-guo，ZHONG Yu-hang，CAI Xiao-juan，YE Li-xin，XIE Cai-lian
(Dongguan City Maternal and Child Health Care Neonatal Disease Screening Center，Dongguan 523000，Guangdong，China)
Abstract：Objective To investigate the birth weight of neonatal thyroid stimulating hormone(TSH)level and with congenital hypothyroidism(CH) incidence.Methods Using fluorescence enzyme immunoassay method for plantar blood TSH in 226390 cases of neonatal screening，TSH≥9 mU/L for screening positive，if TSH was still ≥9 mU/L recall is the determination of TSH，FT3，FT4.The diagnosis were grouped according to the different birth weight，TSH level and CH analysis of different birth weight of newborns.Results The incidence of different birth weight neonatal TSH screening positive rate difference was statistically significant(P<0.05)，there were statistically significant differences in the incidence rate of CH(P<0.05). Conclusion Neonatal TSH levels，CH incidence and neonatal birth weight.Low birth weight TSH screening positive rate is low.Low birth weight children，the incidence of huge children higher.In order to prevent the low birth weight of children with low TSH caused by screening false negative，in the neonatal screening stage of low birth weight should be delayed acquisition of heel blood TSH.Attention to health care during pregnancy to prevent huge children，low birth weight children，to reduce the occurrence of congenital thyroid dysfunction is of great significance.
, 百拇医药
Key words：Neonatal screening；Congenital hypothyroidism；Birth weight；Thyrotropin；Incidence
先天性甲状腺功能低下(CH)是一种由于先天性原因使甲状腺激素合成障碍、甲状腺素缺乏而导致患儿生长迟缓、智力发育落后的一种常见的内分泌疾病。该病在新生儿期往往因为症状轻微或者缺乏典型的甲状腺功能低下的症状和体征容易误诊。通过新生儿疾病筛查有利于本病早期发现，早期治疗。为了解比较不同出生体重新生儿的促甲状腺素(TSH)水平和CH发病率，本文对226390例新生儿筛查血片TSH检测结果及临床确诊结果进行统计分析，报告如下。
1 资料与方法
1.1一般资料
东莞市出生的有出生体重信息的活产新生儿共226390例。, http://www.100md.com(陈锦国 钟玉杭 蔡小娟 叶立新 谢彩连)
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