老年Ⅰ期周围型非小细胞肺癌大分割三维适形放射治疗疗效分析(1)

http://www.100md.com 2017年6月11日 医学信息 2017年第23期

     摘要：目的 探讨大分割三维适形放射(3DCRT)治疗老年周围型非小细胞肺癌的疗效及毒性反应。方法 32例老年Ⅰ期周围型非小细胞肺癌(NSCLC)随机分成三维适形大分割放疗组和常规分割放疗组。其中大分割放疗组15例，处方剂量DT 48～60 Gy，3～6 Gy/次，5次/w；常规分割放疗组17例，处方剂量DT 66 Gy，2 Gy/次，5次/w。结果 大分割放疗组和常规分割放疗组完全缓解(CR)率分别为40.00%、17.70%，部分缓解(PR)率分别为46.70%、23.50%，有效率(CR+PR)分别为86.70%、41.20%(P<0.05)；1、2、3年生存率大分割放疗组分别为80.00%、53.30%、33.30%，常规分割放疗组分别为47.10%、23.50%、17.60%。放射性食管炎和放射性肺炎发生率相当。结论 大分割三维适形放疗治疗老年Ⅰ期周围型非小细胞肺癌的效果优于常规分割放疗，且不良反应相当。

    关键词：非小细胞肺癌；周围型；放射治疗；预后

, http://www.100md.com     中图分类号：R734.2 文献标识码：A 文章编号：1006-1959(2017)23-0044-02

    Analysis of Curative Effect of Three Dimensional Conformal Radiotherapy for Elderly Patients with Stage I Peripheral non-small Cell Lung Cancer

    CHEN Xiao-hua，LI Shu-ping，HE Jin-xiang，QI Ning，ZHANG Zhu-xiang，WANG Ning，LIN Hui-qin

    (Department of Radiology，First Hospital Affiliated to Lanzhou University，Lanzhou 730000，Gansu，China)
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    Abstract：Objective To investigate the hypofractionated three-dimensional conformal radiotherapy(3DCRT)efficacy and toxicity in treatment of elderly patients with non small cell lung cancer.Methods 32 cases of elderly patients with stage I non small cell lung cancer(NSCLC)were randomly divided into three-dimensional conformal radiotherapy group and conventional radiotherapy group.Among them，15 cases were divided into radiotherapy group，prescription dose DT 48～60 Gy，3～6 Gy/times，5 times/w；Conventional radiotherapy group 17 cases，prescription dose DT 66 Gy，2 Gy/times，5 times/w.Results Hypofractionated radiotherapy group and conventional radiotherapy group complete remission(CR)rate were 40.00%，17.70%，partial remission(PR)rate were 46.70%，23.50%，efficiency(CR+PR)were 86.70% and 41.20%(P<0.05)；1，2，3 year survival rate of radiotherapy group were 80.00%and 53.30%.33.30%，conventional radiotherapy group were 47.10%，23.50%，17.60%.The incidence of radiation esophagitis and radiation pneumonitis was similar.Conclusion The effect of large fractionated three-dimensional conformal radiotherapy for elderly patients with stage I peripheral non-small cell lung cancer is better than that of conventional fractionated radiotherapy，and the adverse reactions are similar.
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    Key words：Non small cell lung cancer；Peripheral type；Radiotherapy；Prognosis

    非小細胞肺癌(non-small cell lung cancer，NSCLC)已成为最常见的恶性肿瘤，主要发病年龄段在50～80岁，中位年龄为70岁左右[1]。其中28%为早期肺癌(即Ⅰ期肺癌，T1-2aN0M0)。老年患者常因有严重的内科合并症、心肺功能不足或拒绝手术，放射治疗是标准的治疗模式[2]。为进一步探讨大分割放疗对不能手术的老年周围型肺癌患者放疗效果和不良反应，本研究收集并分析了2008年11月～2012年12月本科室收治的32例老年Ⅰ期周围型非小细胞肺癌肺癌患者，按接受的分割方式不同分为三维适形大分割放射治疗组15例和三维适形常规分割放射治疗组17例，放疗结束后随访观察不良反应，评估放疗疗效，现报告如下。, 百拇医药(陈小华 李淑萍 何津祥 祁宁 张珠祥 王宁 林慧琴)

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