西咪替丁联合泮托拉唑治疗急性胃黏膜病变并出血的临床观察(1)
摘 要：目的 分析西咪替丁联合泮托拉唑治疗急性胃黏膜病变(AGML)并出血的临床观察。方法 选择本院2016年8月～2017年8月接收的64例AGML并出血患者资料，随机分为研究组和对照组，各32例。对照组行西咪替丁治疗，而研究组以西咪替丁和泮托拉唑联合治疗，对比两组治疗患者空腹胃液pH值，VAS评分和不良反应发生情况。结果 研究组空腹胃液pH值、VAS评分指标均优于对照组，差异具有统计学意义(P<0.05)；研究组不良反应发生率(3.13%)明显低于对照组(25.00%)，差异具有统计学意义(P<0.05)。结论 西咪替丁联合泮托拉唑应用于AGML并出血患者的总体效果好，可使患者疼痛度减轻，不良反应相对单纯性应用西咪替丁少。
关键词：泮托拉唑；急性胃黏膜病变；西咪替丁；出血
中图分类号：R573 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.00.049
, http://www.100md.com
文章编号：1006-1959(2018)02-0133-02
Abstract：Objective To analyze the clinical observation of cimetidine combined with pantoprazole in the treatment of acute gastric mucosal lesions (AGML)and bleeding.Methods A total of 64 patients with AGML and bleed received in our hospital from August 2016 to August 2017 were randomly divided into study group(32 cases)and control group(32 cases).The control group was treated with cimetidine， while the study group was treated with cimetidine and pantoprazole. The fasting gastric juice pH value， VAS score and adverse reactions were compared between the two groups.Results The fasting gastric juice pH value and VAS score were all higher in the study group than those in the control group，the difference was statistically significant(P<0.05).The incidence of adverse reactions in the study group(3.13%)was significantly lower than that in the control group(25.00%)，the difference was statistically significant(P<0.05).Conclusion The application of cimetidine combined with pantoprazole in patients with AGML and hemorrhage has a good overall effect，which can reduce the degree of pain and reduce the adverse reaction of cimetidine.
, http://www.100md.com
Key words：Pantoprazole；Acute gastric mucosal lesions；Cimetidine；Bleeding
急性胃粘膜病變(acute gastric mucosal lesions，AGML)通常为机体在严重创伤、应激状态中及胃肠在接触特定物质后引起胃肠粘膜发生糜烂、出血的统称[1]。AGML并出血是上消化道出血的主要原因之一，多是因感染、手术、创伤、多器官、功能的衰退及休克等因素引起，对患者生活会造成严重影响。药物治疗仍是目前治疗AGML并出血的首选方法。选取本院64例AGML并出血患者，对西咪替丁联合泮托拉唑治疗的临床效果进行探究，现报道如下。
1资料与方法
1.1一般资料 选择本院2016年8月～2017年8月接收的64例AGML并出血患者资料，所有程序通过医院伦理委员会批准。纳入标准：①经胃镜进行检查后已确诊者，溃疡面积为0.50～3.00 cm2；②与急性胃粘膜病变并出血症状相符者；③同意签署知情同意书者。排除标准：①存在药物过敏史或精神异常者；②哺乳期或是妊娠期的妇女；③由门静脉高压引发致的静脉曲张的破裂性出血者。将患者分为研究组和对照组各32例。对照组男19例，女13例；年龄47～79岁，平均年龄(54.23±3.27)岁；病程4～15年，平均病程(6.29±2.58)年。研究组男20例，女12例；年龄49～78岁，平均年龄(56.32±2.61)岁；病程3～14年，平均病程(6.01±2.10)年。基线资料在两组中对比不存在统计意义(P>0.05)，有可比性。
1.2方法 对照组行西咪替丁治疗。西咪替丁(山东方明药业集团股份有限公司，国药准字H37023309)400 mg加入250 ml 5%葡萄糖溶液中，以静滴形式给药，2次/d。研究组以西咪替丁和泮托拉唑联合治疗。西咪替丁和对照组同，再取泮托拉唑(扬子江药业集团有限公司，国药准字H19990170)40 mg，注入100 ml的生理盐水中实施静滴，1次/d。两组患者1疗程均为5 d，连续治疗6个疗程。, http://www.100md.com(龚立云)
关键词：泮托拉唑；急性胃黏膜病变；西咪替丁；出血
中图分类号：R573 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.00.049
, http://www.100md.com
文章编号：1006-1959(2018)02-0133-02
Abstract：Objective To analyze the clinical observation of cimetidine combined with pantoprazole in the treatment of acute gastric mucosal lesions (AGML)and bleeding.Methods A total of 64 patients with AGML and bleed received in our hospital from August 2016 to August 2017 were randomly divided into study group(32 cases)and control group(32 cases).The control group was treated with cimetidine， while the study group was treated with cimetidine and pantoprazole. The fasting gastric juice pH value， VAS score and adverse reactions were compared between the two groups.Results The fasting gastric juice pH value and VAS score were all higher in the study group than those in the control group，the difference was statistically significant(P<0.05).The incidence of adverse reactions in the study group(3.13%)was significantly lower than that in the control group(25.00%)，the difference was statistically significant(P<0.05).Conclusion The application of cimetidine combined with pantoprazole in patients with AGML and hemorrhage has a good overall effect，which can reduce the degree of pain and reduce the adverse reaction of cimetidine.
, http://www.100md.com
Key words：Pantoprazole；Acute gastric mucosal lesions；Cimetidine；Bleeding
急性胃粘膜病變(acute gastric mucosal lesions，AGML)通常为机体在严重创伤、应激状态中及胃肠在接触特定物质后引起胃肠粘膜发生糜烂、出血的统称[1]。AGML并出血是上消化道出血的主要原因之一，多是因感染、手术、创伤、多器官、功能的衰退及休克等因素引起，对患者生活会造成严重影响。药物治疗仍是目前治疗AGML并出血的首选方法。选取本院64例AGML并出血患者，对西咪替丁联合泮托拉唑治疗的临床效果进行探究，现报道如下。
1资料与方法
1.1一般资料 选择本院2016年8月～2017年8月接收的64例AGML并出血患者资料，所有程序通过医院伦理委员会批准。纳入标准：①经胃镜进行检查后已确诊者，溃疡面积为0.50～3.00 cm2；②与急性胃粘膜病变并出血症状相符者；③同意签署知情同意书者。排除标准：①存在药物过敏史或精神异常者；②哺乳期或是妊娠期的妇女；③由门静脉高压引发致的静脉曲张的破裂性出血者。将患者分为研究组和对照组各32例。对照组男19例，女13例；年龄47～79岁，平均年龄(54.23±3.27)岁；病程4～15年，平均病程(6.29±2.58)年。研究组男20例，女12例；年龄49～78岁，平均年龄(56.32±2.61)岁；病程3～14年，平均病程(6.01±2.10)年。基线资料在两组中对比不存在统计意义(P>0.05)，有可比性。
1.2方法 对照组行西咪替丁治疗。西咪替丁(山东方明药业集团股份有限公司，国药准字H37023309)400 mg加入250 ml 5%葡萄糖溶液中，以静滴形式给药，2次/d。研究组以西咪替丁和泮托拉唑联合治疗。西咪替丁和对照组同，再取泮托拉唑(扬子江药业集团有限公司，国药准字H19990170)40 mg，注入100 ml的生理盐水中实施静滴，1次/d。两组患者1疗程均为5 d，连续治疗6个疗程。, http://www.100md.com(龚立云)