齐拉西酮与奥氮平治疗首发精神分裂症疗效及糖脂代谢的影响观察(1)
摘 要：目的 研究齐拉西酮与奥氮平治疗首发精神分裂症疗效及用药后对患者机体糖脂代谢的影响。方法 选取我院精神病科2016年1月～2017年5月收治并接受治疗的精神分裂症患者68例，随机分为对照组和观察组，每组34例。观察组采用齐拉西酮进行治疗，对照组采用奥氮平进行治疗，对比两组患者临床疗效、FBG、TG、LDL-C、HDL-C、TC的变化情况，以及不良反应情况。结果 两组患者治疗有效率均为88.20%，差异无统计学意义(P>0.05)；对照组患者血清总胆固醇(TC)、血糖(FBG)分别为(4.62±0.31)mmol/L、(5.67±0.29)mmol/L，高于观察组的(3.91±0.28)mmol/L、(5.13±0.35)mmol/L，差异具有统计学意义(P<0.05)。治疗后两组患者FBG、TG、LDL-C、HDL-C、TC指标均有一定程度变化，其中观察组患者三酰甘油(TG)为(1.25±0.35)mmol/L，高于对照组的(0.84±0.37)mmol/L，差异具有统计学意义(P<0.05)。观察组患者服药后出现较为明显的震颤情况，震颤比例26.47%，高于对照组患者的8.82%，差异具有统计学意义(P<0.05)。结论 齐拉西酮与奥氮平治疗首发精神分裂症疗效基本一致，糖脂代谢及不良反应具有一定差异，在临床应结合患者实际情况选择合适的治疗方案，以便患者病情的康复及减少不良反应发生。
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关键词：齐拉西酮；奥氮平；精神分裂症；糖脂代謝
中图分类号：R749.3 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.06.044
文章编号：1006-1959(2018)06-0130-03
The Effect of Ziprasidone and Olanzapine in the Treatment of First Episode Schizophrenia and the Effect of Glycolipid Metabolism
SHEN XUE-mei
(Outpatient Pharmacy of the Fourth People's Hospital in Xuancheng，Xuancheng 242000，Anhui，China)
, 百拇医药
Abstract：Objective To study the efficacy of ziprasidone and olanzapine in the treatment of first-episode schizophrenia and the effects of ziprasidone and olanzapine on glucose and lipid metabolism.Methods In our hospital psychiatric department in January 2016 to 2017 year in May 68 cases of schizophrenia patients were treated and randomly divided into control group and observation group，with 34 cases in each group.The observation group received ziprasidone treatment，the control group were treated with olanzapine，clinical curative effect，compared with two groups of FBG，TG，LDL-C，HDL-C.The change of TC， and adverse reacts.Results The effective rate of treatment in both groups was 88.20%，the difference was not significant(P>0.05)，the serum total cholesterol(TC) and blood glucose(FBG)in the control group were(4.62±0.31)mmol/L and(5.67±0.29)mmol/L，respectively，which were higher than those in the observation group(3.91±0.28)mmol/L and(5.13±0.35)mmol/L，the difference was statistically significant(P<0.05).After treatment，the FBG，TG，LDL-C，HDL-C and TC indexes of the two groups changed to some extent.The three glycerol(TG)in the observation group was(1.25±0.35)mmol/L， which was higher than that in the control group(0.84±0.37)mmol/L，the difference was statistically significant(P<0.05).The patients in the observation group had a more obvious tremor after taking medicine，and the proportion of tremors was 26.47%，which was higher than that in the control group(8.82%).The difference was statistically significant(P<0.05).Conclusion The efficacy of ziprasidone and olanzapine in the treatment of first-episode schizophrenia is basically the same.There are certain differences between glucose and lipid metabolism and adverse reactions.In clinical practice，we should choose the appropriate treatment plan according to the actual situation of patients，so as to restore the patient's condition and reduce the incidence of adverse reactions., 百拇医药(沈雪梅)
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关键词：齐拉西酮；奥氮平；精神分裂症；糖脂代謝
中图分类号：R749.3 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.06.044
文章编号：1006-1959(2018)06-0130-03
The Effect of Ziprasidone and Olanzapine in the Treatment of First Episode Schizophrenia and the Effect of Glycolipid Metabolism
SHEN XUE-mei
(Outpatient Pharmacy of the Fourth People's Hospital in Xuancheng，Xuancheng 242000，Anhui，China)
, 百拇医药
Abstract：Objective To study the efficacy of ziprasidone and olanzapine in the treatment of first-episode schizophrenia and the effects of ziprasidone and olanzapine on glucose and lipid metabolism.Methods In our hospital psychiatric department in January 2016 to 2017 year in May 68 cases of schizophrenia patients were treated and randomly divided into control group and observation group，with 34 cases in each group.The observation group received ziprasidone treatment，the control group were treated with olanzapine，clinical curative effect，compared with two groups of FBG，TG，LDL-C，HDL-C.The change of TC， and adverse reacts.Results The effective rate of treatment in both groups was 88.20%，the difference was not significant(P>0.05)，the serum total cholesterol(TC) and blood glucose(FBG)in the control group were(4.62±0.31)mmol/L and(5.67±0.29)mmol/L，respectively，which were higher than those in the observation group(3.91±0.28)mmol/L and(5.13±0.35)mmol/L，the difference was statistically significant(P<0.05).After treatment，the FBG，TG，LDL-C，HDL-C and TC indexes of the two groups changed to some extent.The three glycerol(TG)in the observation group was(1.25±0.35)mmol/L， which was higher than that in the control group(0.84±0.37)mmol/L，the difference was statistically significant(P<0.05).The patients in the observation group had a more obvious tremor after taking medicine，and the proportion of tremors was 26.47%，which was higher than that in the control group(8.82%).The difference was statistically significant(P<0.05).Conclusion The efficacy of ziprasidone and olanzapine in the treatment of first-episode schizophrenia is basically the same.There are certain differences between glucose and lipid metabolism and adverse reactions.In clinical practice，we should choose the appropriate treatment plan according to the actual situation of patients，so as to restore the patient's condition and reduce the incidence of adverse reactions., 百拇医药(沈雪梅)