颈动脉斑块、血同型半胱氨酸及血尿酸对短暂性脑缺血发作进程的影响研究(1)
摘 要：目的 探討不同病程短暂性脑缺血发作(TIA)患者血清同型半胱氨酸(HCY)、血清尿酸(UA)含量的变化及临床意义。方法 选取2013年6月～2017年6月在我院神经内科住院的患者80例，根据TIA最终是否进展为脑梗死分为A组(TIA未进展为脑梗死者)和B组(TIA在24～48 h经头颅CT或MRA检查证实有脑梗死发生者)，每组40例。另选取同期我院40例健康体检者作为对照组。所有患者及健康体检者均行血清同型半胱氨酸及血清尿酸水平并进行分析，其中A、B两组分别行颈动脉超声检查，并对两组患者颈动脉斑块性质进行比较。结果 B组患者血同型半胱氨酸和血尿酸水平均高于A组和对照组，差异具有统计学意义(P<0.05)；A组血同型半胱氨酸和血尿酸水平高于对照组，差异具有统计学意义(P<0.05)。A组检出硬斑块15例，软斑块10例；B组检出硬斑块10例，软斑块25例；B组颈动脉软斑块检出率为62.50%，高于A组的25.00%，差异有统计学意义(P<0.05)。结论 血同型半胱氨酸和血尿酸水平升高及颈动脉斑块尤其是不稳定斑块可能是TIA患者的危险因素，也是TIA患者早期展为脑梗死的重要危险因素。早期发现血同型半胱氨酸、血尿酸水平升高及颈动脉斑块可作为TIA患者的病情评估依据，并对TIA患者是否进一步进展为脑梗死具有一定的预测作用，故可进行早期干预，进而预防TIA患者进一步进展为脑梗死。
, 百拇医药
关键词：短暂性脑缺血发作；脑梗死；血尿酸；血同型半胱氨酸；颈动脉斑块
中图分类号：R743.31 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.08.020
文章编号：1006-1959(2018)08-0065-04
Effects of Carotid Plaque，Homocysteine and Serum Uric Acid on Transient Ischemic Attack
WANG Ming-yuan1，CHEN Hai-yan1，ZHANG Yan-peng1，LIU Ning1，REN Li-na2
(1.Department of Neurology，First Hospital of Lanzhou University，Lanzhou 730000，Gansu，China；
, 百拇医药
2.Department of Mental Health，Second Hospital of Lanzhou University，Lanzhou 730000，Gansu，China)
Abstract：Objective To investigate the changes and clinical significance of serum homocysteine(HCY)and serum uric acid(UA)in patients with transient ischemic attack(TIA).Methods 80 patients were enrolled in our department of neurology from June 2013 to June 2017.According to whether the TIA eventually progressed to cerebral infarction，they were divided into group A(TIA without progression to cerebral infarction)and group B(TIA at 24～48 h after brain CT or MRA examination confirmed the occurrence of cerebral infarction)，40 cases in each group.In the same period，40 healthy persons in our hospital were selected as the control group.The serum homocysteine and serum uric acid levels were analyzed in all patients and healthy controls.Carotid artery ultrasound was performed in group A and B，and the plaques of carotid artery in two groups were compared.Results The levels of homocysteine and uric acid in group B were significantly higher than those in group A and control group，the difference was statistically significant(P<0.05).The levels of homocysteine and serum uric acid in group A were higher than those in the control group，and the differences were statistically significant(P<0.05).In group A，there were 15 cases of hard plaques and 10 cases of soft plaques；10 cases of hard plaques and 25 cases of soft plaques were detected in group B；The detection rate of carotid soft plaque in group B was 62.50%，which was higher than that in group A 25.00% the difference was statistically significant(P<0.05).Conclusion Increased levels of homocysteine and serum uric acid and carotid plaque，especially unstable plaque， may be risk factors for TIA patients，and it is also an important risk factor for TIA patients to develop early cerebral infarction.Early detection of homocysteine，elevated serum uric acid levels，and carotid plaque can be used as the basis for assessing the condition of patients with TIA，and it can predict the progression of TIA patients to cerebral infarction.Therefore，early intervention can be performed.This in turn prevents the progression of TIA patients to cerebral infarction., 百拇医药(王明远 陈海燕 张延朋 刘宁 任丽娜)
, 百拇医药
关键词：短暂性脑缺血发作；脑梗死；血尿酸；血同型半胱氨酸；颈动脉斑块
中图分类号：R743.31 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.08.020
文章编号：1006-1959(2018)08-0065-04
Effects of Carotid Plaque，Homocysteine and Serum Uric Acid on Transient Ischemic Attack
WANG Ming-yuan1，CHEN Hai-yan1，ZHANG Yan-peng1，LIU Ning1，REN Li-na2
(1.Department of Neurology，First Hospital of Lanzhou University，Lanzhou 730000，Gansu，China；
, 百拇医药
2.Department of Mental Health，Second Hospital of Lanzhou University，Lanzhou 730000，Gansu，China)
Abstract：Objective To investigate the changes and clinical significance of serum homocysteine(HCY)and serum uric acid(UA)in patients with transient ischemic attack(TIA).Methods 80 patients were enrolled in our department of neurology from June 2013 to June 2017.According to whether the TIA eventually progressed to cerebral infarction，they were divided into group A(TIA without progression to cerebral infarction)and group B(TIA at 24～48 h after brain CT or MRA examination confirmed the occurrence of cerebral infarction)，40 cases in each group.In the same period，40 healthy persons in our hospital were selected as the control group.The serum homocysteine and serum uric acid levels were analyzed in all patients and healthy controls.Carotid artery ultrasound was performed in group A and B，and the plaques of carotid artery in two groups were compared.Results The levels of homocysteine and uric acid in group B were significantly higher than those in group A and control group，the difference was statistically significant(P<0.05).The levels of homocysteine and serum uric acid in group A were higher than those in the control group，and the differences were statistically significant(P<0.05).In group A，there were 15 cases of hard plaques and 10 cases of soft plaques；10 cases of hard plaques and 25 cases of soft plaques were detected in group B；The detection rate of carotid soft plaque in group B was 62.50%，which was higher than that in group A 25.00% the difference was statistically significant(P<0.05).Conclusion Increased levels of homocysteine and serum uric acid and carotid plaque，especially unstable plaque， may be risk factors for TIA patients，and it is also an important risk factor for TIA patients to develop early cerebral infarction.Early detection of homocysteine，elevated serum uric acid levels，and carotid plaque can be used as the basis for assessing the condition of patients with TIA，and it can predict the progression of TIA patients to cerebral infarction.Therefore，early intervention can be performed.This in turn prevents the progression of TIA patients to cerebral infarction., 百拇医药(王明远 陈海燕 张延朋 刘宁 任丽娜)