β受体阻滞剂预处理对AMI介入治疗患者心室重构、自主神经功能恢复的影响研究(1)
摘 要：目的 研究β受體阻滞剂预处理对急性心肌梗塞(AMI)介入治疗患者心室重构、自主神经功能恢复的影响。方法 收集我院自2015年9月～2017年9月收治的接受介入手术治疗的AMI患者90例作为观察对象，按随机数字表法分为观察组与对照组，每组45例。对照组早期给予常规药物干预，观察组则在对照组的基础上增加β受体阻滞剂行预处理。评估并对比两组心室重构、自主神经功能改善及预后情况。结果 治疗后，两组ESVI、血清MMP-2指标均低于入院时(P<0.05)，且观察组低于同时期对照组(P<0.05)；两组EDVI、LVEF均高于入院时(P<0.05)，且观察组高于同时期对照组(P<0.05)。治疗后，两组SDNN、SDANN指标均升高，且观察组高于同时期对照组(P<0.05)，接近正常水平；而两组治疗后LF/HF均低于入院时(P<0.05)，且观察组低于同时期的对照组(P<0.05)。随访半年，两组心血管事件发生率比较，差异无统计学意义(P>0.05)。结论 β受体阻滞剂预处理能够改善AMI介入治疗患者心室重构及自主神经功能，改善预后，具有较高的推广价值。
, 百拇医药
关键词：β受体阻滞剂；AMI；介入治疗；心室重构；自主神经功能
中图分类号：R542.22 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.09.027
文章编号：1006-1959(2018)09-0091-03
Abstract：Objective To study the effects of β-blocker preconditioning on ventricular remodeling and autonomic nerve function recovery in patients with acute myocardial infarction(AMI).Methods We collected 90 cases of AMI patients undergoing interventional surgery in our hospital from September 2015 to September 2017 as observation objects，and were divided into observation group and control group according to the random number table method，45 cases in each group.The control group received conventional drug intervention at an early stage，while the observation group increased β-blocker pretreatment on the basis of the control group.The ventricular remodeling，improvement of autonomic function and prognosis of the two groups were assessed and compared.Results After treatment，the serum levels of ESVI and MMP-2 in both groups were lower than those at admission(P<0.05)，and the observation group was lower than the control group at the same time(P<0.05).Both EDVI and LVEF were higher than those at the time of admission(P<0.05)，and the observation group was higher than the control group at the same time(P<0.05).After treatment，both SDNN and SDANN indicators increased，and the observation group was higher than the control group at the same time(P<0.05)，and was close to the normal level； and the LF/HF of the two groups was lower than that of the admission(P<0.05).The observation group was lower than the control group in the same period(P<0.05).After six months of follow-up，there was no statistically significant difference in the incidence of cardiovascular events between the two groups(P>0.05).Conclusion β-blocker preconditioning can improve the ventricular remodeling and autonomic function of patients undergoing AMI intervention and improve their prognosis.It has a higher value of promotion.
Key words：β-blockers；AMI；Interventional therapy；Ventricular remodeling；Autonomic nervous system function, 百拇医药(李铎)
, 百拇医药
关键词：β受体阻滞剂；AMI；介入治疗；心室重构；自主神经功能
中图分类号：R542.22 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.09.027
文章编号：1006-1959(2018)09-0091-03
Abstract：Objective To study the effects of β-blocker preconditioning on ventricular remodeling and autonomic nerve function recovery in patients with acute myocardial infarction(AMI).Methods We collected 90 cases of AMI patients undergoing interventional surgery in our hospital from September 2015 to September 2017 as observation objects，and were divided into observation group and control group according to the random number table method，45 cases in each group.The control group received conventional drug intervention at an early stage，while the observation group increased β-blocker pretreatment on the basis of the control group.The ventricular remodeling，improvement of autonomic function and prognosis of the two groups were assessed and compared.Results After treatment，the serum levels of ESVI and MMP-2 in both groups were lower than those at admission(P<0.05)，and the observation group was lower than the control group at the same time(P<0.05).Both EDVI and LVEF were higher than those at the time of admission(P<0.05)，and the observation group was higher than the control group at the same time(P<0.05).After treatment，both SDNN and SDANN indicators increased，and the observation group was higher than the control group at the same time(P<0.05)，and was close to the normal level； and the LF/HF of the two groups was lower than that of the admission(P<0.05).The observation group was lower than the control group in the same period(P<0.05).After six months of follow-up，there was no statistically significant difference in the incidence of cardiovascular events between the two groups(P>0.05).Conclusion β-blocker preconditioning can improve the ventricular remodeling and autonomic function of patients undergoing AMI intervention and improve their prognosis.It has a higher value of promotion.
Key words：β-blockers；AMI；Interventional therapy；Ventricular remodeling；Autonomic nervous system function, 百拇医药(李铎)