普查人群内镜下卢戈氏液染色在食管癌前病变的应用价值(1)
摘 要：目的 了解恶性肿瘤高发区普查人群内镜下卢戈氏液染色食管粘膜改变的情况，探讨内镜下卢戈氏液染色在食管癌前病变的应用价值。方法 收集2017年11月～12月104例普查者在我院胃镜普查，先直视下观察，然后食管用1.5%的卢戈氏液染色，观察染色前后食管粘膜的着色情况，进行分析。结果 104例普查者的食管病变总感染率为50.96%，其中男性食管病变感染率为56.00%，女性食管病变感染率为46.30%，年龄性别差异无统计学意义(P均>0.05)；卢戈氏碘液染后检查显示：食管病变检出率随着年龄的增长而增长。结论 普查人群内镜下应用卢戈氏液染色法是诊断食管癌前病变较好的方法，能明显提高食管癌前病变检出率，有助于食管癌前病变的诊断与鉴别诊断，对高发人群应加强预防及早诊早治。
关键词：普查人群；卢戈氏液；染色；癌前病变
中图分类号：R735 文献标识码：B DOI：10.3969/j.issn.1006-1959.2018.09.062
, 百拇医药
文章编号：1006-1959(2018)09-0185-02
Abstract：Objective To investigate the changes of esophageal mucosa with Lugo's solution staining under endoscopy in high incidence area of malignant tumor， and to explore the value of Lugo's solution staining for precancerous lesions of esophagus.Methods A total of 104 cases of census from November to December of 2017 were collected under gastroscopy in our hospital and observed under direct vision.Then the esophagus was stained with 1.5% Lugo's solution staining to observe the coloration of esophageal mucosa before and after staining.Results The total infection rate of esophageal lesions in 104 cases was 50.96%，of which the infection rate of male esophagus was 56.00%，the infection rate of female esophagus was 46.30%，and the difference of age and sex was not statistically significant(P>0.05).The detection of Lugo's solution iodine staining showed that the detection rate of esophageal lesions increased with age.Conclusion The application of Lugo's solution staining to endoscopy is a better method for the diagnosis of precancerous lesions of the esophagus.It can obviously improve the detection rate of precancerous lesions of the esophagus，help the diagnosis and differential diagnosis of the precancerous lesions of the esophagus，and strengthen the prevention and early diagnosis and early treatment for the high incidence population.
, 百拇医药
Key words：Census population；Lugo's solution；Staining；Precancerous lesion
扬中市是消化道肿瘤高发区，贲门癌年粗发病率90.6/10万，胃癌粗发病率141.85/10万，在全国排名前列[1]。目前，食管的癌前病变主要有慢性食管炎、食管上皮增生、食管潰疡、食管白斑等，及早防治可提高食管癌前病变检出，对防治食管癌有十分重要意义。食管癌前病变及早期食管癌临床症状和内镜下表现都不明显及典型。内镜下食管不进行碘染色对于癌前病变诊断率不高，容易漏诊[2]。内镜下卢戈氏碘液染色对非角化的鳞状上皮呈着色或深染，而对癌变和不典型增生的鳞状上皮，呈不着色或淡染色，两者有明显的区别。因此，可以提高活检的准确性。食管癌前病变和早期食管癌可采用日本著名学者Yamakawa 19世纪70年代首创的[3]镜下喷洒卢戈氏碘液染色法，这种方法可大大提高食管癌前病变和早期食管癌诊断率[4]。
1 资料与方法
1.1一般资料 对江苏省扬中市消化道肿瘤高发区进行普查，共普查人群106例，扣除房颤1例，未到检1例，纳入研究计104例，人群年龄39～59岁，无胃镜检查、卢戈氏液等相关禁忌症。对普查人群进行胃镜检查时同时进行食管用1.5% 的卢戈液碘液染色，观察食管粘膜的变化情况进行分析。
1.2仪器 胃镜 Olympus Q260 J系列，主机 CV-260SL，光源为 CLV-260SL 喷雾塑料导管，活检钳。, 百拇医药(郭丽梅 郭江川 华召来 施爱武 周琴)
关键词：普查人群；卢戈氏液；染色；癌前病变
中图分类号：R735 文献标识码：B DOI：10.3969/j.issn.1006-1959.2018.09.062
, 百拇医药
文章编号：1006-1959(2018)09-0185-02
Abstract：Objective To investigate the changes of esophageal mucosa with Lugo's solution staining under endoscopy in high incidence area of malignant tumor， and to explore the value of Lugo's solution staining for precancerous lesions of esophagus.Methods A total of 104 cases of census from November to December of 2017 were collected under gastroscopy in our hospital and observed under direct vision.Then the esophagus was stained with 1.5% Lugo's solution staining to observe the coloration of esophageal mucosa before and after staining.Results The total infection rate of esophageal lesions in 104 cases was 50.96%，of which the infection rate of male esophagus was 56.00%，the infection rate of female esophagus was 46.30%，and the difference of age and sex was not statistically significant(P>0.05).The detection of Lugo's solution iodine staining showed that the detection rate of esophageal lesions increased with age.Conclusion The application of Lugo's solution staining to endoscopy is a better method for the diagnosis of precancerous lesions of the esophagus.It can obviously improve the detection rate of precancerous lesions of the esophagus，help the diagnosis and differential diagnosis of the precancerous lesions of the esophagus，and strengthen the prevention and early diagnosis and early treatment for the high incidence population.
, 百拇医药
Key words：Census population；Lugo's solution；Staining；Precancerous lesion
扬中市是消化道肿瘤高发区，贲门癌年粗发病率90.6/10万，胃癌粗发病率141.85/10万，在全国排名前列[1]。目前，食管的癌前病变主要有慢性食管炎、食管上皮增生、食管潰疡、食管白斑等，及早防治可提高食管癌前病变检出，对防治食管癌有十分重要意义。食管癌前病变及早期食管癌临床症状和内镜下表现都不明显及典型。内镜下食管不进行碘染色对于癌前病变诊断率不高，容易漏诊[2]。内镜下卢戈氏碘液染色对非角化的鳞状上皮呈着色或深染，而对癌变和不典型增生的鳞状上皮，呈不着色或淡染色，两者有明显的区别。因此，可以提高活检的准确性。食管癌前病变和早期食管癌可采用日本著名学者Yamakawa 19世纪70年代首创的[3]镜下喷洒卢戈氏碘液染色法，这种方法可大大提高食管癌前病变和早期食管癌诊断率[4]。
1 资料与方法
1.1一般资料 对江苏省扬中市消化道肿瘤高发区进行普查，共普查人群106例，扣除房颤1例，未到检1例，纳入研究计104例，人群年龄39～59岁，无胃镜检查、卢戈氏液等相关禁忌症。对普查人群进行胃镜检查时同时进行食管用1.5% 的卢戈液碘液染色，观察食管粘膜的变化情况进行分析。
1.2仪器 胃镜 Olympus Q260 J系列，主机 CV-260SL，光源为 CLV-260SL 喷雾塑料导管，活检钳。, 百拇医药(郭丽梅 郭江川 华召来 施爱武 周琴)