幽门螺杆菌抗体、胃泌素17、胃蛋白酶原等联合检测在体检人群胃疾病筛查中的意义(1)
摘 要：目的 探討分析幽门螺杆菌抗体、胃泌素17、胃蛋白酶原Ⅰ、Ⅱ及PGR联合检测在体检人群胃疾病筛查中的意义。方法 选取2016年1月～2017年12月来我院体检中心选择同时包含胃镜、胃泌素17、胃蛋白酶原及幽门螺杆菌抗体检查项目的受检者271例，分为经胃镜检查(部分行活检病理)证实的胃溃疡组49例，萎缩性胃炎组86例，癌前病变和胃癌组36例，经胃镜检查无胃疾病或仅有浅表性胃炎的对照组100例。采用放免技术测定体检人群血清中幽门螺杆菌抗体、胃泌素17、胃蛋白酶原Ⅰ、Ⅱ及其比值，同时行胃镜检查，胃镜下活检的病例均以病理诊断为准，对血清学、胃镜以及病理结果进行统计学分析。结果 胃癌前病变及胃癌组患者的五项指标中PGⅠ、PGR均低于其他各组，G-17水平、Hp-Ab阳性率均高于其他各组，差异有统计学意义(P<0.05)。萎缩性胃炎组的G-17水平低于其他各组，差异有统计学意义(P<0.05)。胃溃疡组中G-17和Hp-Ab阳性率的结果与对照组比较，差异有统计学意义(P<0.05)。结论 幽门螺杆菌抗体、胃泌素17、胃蛋白酶原Ⅰ、Ⅱ及PGR的阳性率与胃疾病不同种类及严重程度密切相关，其联合检测在体检人群胃疾病的筛查、鉴别方面有着重要意义。
, http://www.100md.com
关键词：胃疾病；幽门螺杆菌抗体；胃泌素17；胃蛋白酶原
中图分类号：R735.2 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.11.007
文章编号：1006-1959(2018)11-0022-03
The Significance of Combined Detection of Helicobacter Pylori Antibody，Gastrin 17， Pepsinogen，etc.in Gastric Disease Screening in Physical Examination Population
MAO Yi-heng
(Physical Examination Center of Wuxi People's Hospital Affiliated to Nanjing Medical University，Wuxi 214023，Jiangsu，China)
, http://www.100md.com
Abstract：Objective To explore the significance of combined detection of Helicobacter pylori antibody，gastrin 17，pepsinogen I，II，and PGR in gastric screening for physical examination.Methods From January 2016 to December 2017，we selected 271 patients with gastroscope，gastrin 17，pepsinogen，and Helicobacter pylori antibody screening items from our physical examination center and were divided into gastroscopic examinations(partially biopsy pathology)confirmed 49 cases of gastric ulcer group，86 cases of atrophic gastritis group，36 cases of precancerous lesion and gastric cancer group，and 100 cases of gastroscopic examination without gastric disease or superficial gastritis in the control group.The radioimmunoassay was used to determine the levels of Helicobacter pylori antibody， gastrin 17，pepsinogen I，II and its ratio in the serum of the physical examination population.At the same time，gastroscopy and endoscopic biopsy were all based on pathological diagnosis.Serological and gastroscopy were used and pathological results were analyzed statistically.Results The PGI and PGR in the five indicators of gastric precancerous lesions and gastric cancer patients were lower than those in other groups.The levels of G-17 and Hp-Ab positive were higher than those in other groups，and the difference was statistically significant(P<0.05).The level of G-17 in atrophic gastritis group was lower than that in other groups，and the difference was statistically significant(P<0.05).The positive rates of G-17 and Hp-Ab in gastric ulcer group were significantly different from those in the control group，the difference was statistically significant(P<0.05).Conclusion The positive rate of Helicobacter pylori antibody， gastrin 17，pepsinogen I，II and PGR is closely related to the different types and severity of gastric diseases.The joint detection is of great significance in screening and identification of gastric diseases in the physical examination population., http://www.100md.com(茅溢恒)
, http://www.100md.com
关键词：胃疾病；幽门螺杆菌抗体；胃泌素17；胃蛋白酶原
中图分类号：R735.2 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.11.007
文章编号：1006-1959(2018)11-0022-03
The Significance of Combined Detection of Helicobacter Pylori Antibody，Gastrin 17， Pepsinogen，etc.in Gastric Disease Screening in Physical Examination Population
MAO Yi-heng
(Physical Examination Center of Wuxi People's Hospital Affiliated to Nanjing Medical University，Wuxi 214023，Jiangsu，China)
, http://www.100md.com
Abstract：Objective To explore the significance of combined detection of Helicobacter pylori antibody，gastrin 17，pepsinogen I，II，and PGR in gastric screening for physical examination.Methods From January 2016 to December 2017，we selected 271 patients with gastroscope，gastrin 17，pepsinogen，and Helicobacter pylori antibody screening items from our physical examination center and were divided into gastroscopic examinations(partially biopsy pathology)confirmed 49 cases of gastric ulcer group，86 cases of atrophic gastritis group，36 cases of precancerous lesion and gastric cancer group，and 100 cases of gastroscopic examination without gastric disease or superficial gastritis in the control group.The radioimmunoassay was used to determine the levels of Helicobacter pylori antibody， gastrin 17，pepsinogen I，II and its ratio in the serum of the physical examination population.At the same time，gastroscopy and endoscopic biopsy were all based on pathological diagnosis.Serological and gastroscopy were used and pathological results were analyzed statistically.Results The PGI and PGR in the five indicators of gastric precancerous lesions and gastric cancer patients were lower than those in other groups.The levels of G-17 and Hp-Ab positive were higher than those in other groups，and the difference was statistically significant(P<0.05).The level of G-17 in atrophic gastritis group was lower than that in other groups，and the difference was statistically significant(P<0.05).The positive rates of G-17 and Hp-Ab in gastric ulcer group were significantly different from those in the control group，the difference was statistically significant(P<0.05).Conclusion The positive rate of Helicobacter pylori antibody， gastrin 17，pepsinogen I，II and PGR is closely related to the different types and severity of gastric diseases.The joint detection is of great significance in screening and identification of gastric diseases in the physical examination population., http://www.100md.com(茅溢恒)